Publication Name	World Journal of Gastroenterology
Manuscript ID	61811
Country	United States

Received	2020-12-19 13:04
Peer-Review Started	2020-12-19 13:05
To Make the First Decision
Return for Revision	2021-02-11 03:36
Revised	2021-03-22 13:44
Second Decision	2021-06-15 12:50
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2021-06-15 13:20
Articles in Press	2021-06-15 13:20
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2021-06-30 01:53
Publish the Manuscript Online	2021-07-06 02:31

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
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Category	Gastroenterology & Hepatology
Manuscript Type	Review
Article Title	Incorporating mucosal-associated invariant T cells into the pathogenesis of chronic liver disease
Manuscript Source	Invited Manuscript
All Author List	Albert J Czaja
ORCID	Author(s) ORCID Number Albert J Czaja http://orcid.org/0000-0002-5024-3065
Funding Agency and Grant Number
Corresponding Author	Albert J Czaja, FAASLD, AGAF, FACG, FACP, MD, Emeritus Professor, Department of Medicine, Mayo Clinic College of Medicine and Science, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, United States. czaja.albert@mayo.edu
Key Words	Innate-like lymphocytes; Antimicrobial; Immune regulatory; Pathogenic; Mucosal-associated invariant T cell
Core Tip	Circulating mucosal-associated invariant T cells are depleted in chronic liver disease, and they have a disease-nonspecific, hyper-activated, immune exhausted, and dysfunctional phenotype. Antimicrobial, immune regulatory, pro-inflammatory, and anti-inflammatory actions are established biological functions of these innate-like lymphocytes, and each function has been invoked to understand the pathogenesis of chronic hepatitis and cholestatic liver disease. Future investigations must establish their pathological role in each form of chronic liver disease, determine the factors that direct function in the hepatic microenvironment, associate deficient functionality with disease severity and outcome, and explore therapeutic manipulations.
Publish Date	2021-07-06 02:31
Citation	Czaja AJ. Incorporating mucosal-associated invariant T cells into the pathogenesis of chronic liver disease. World J Gastroenterol 2021; 27(25): 3705-3733
URL	https://www.wjgnet.com/1007-9327/full/v27/i25/3705.htm
DOI	https://dx.doi.org/10.3748/wjg.v27.i25.3705

Full Article (PDF)	WJG-27-3705.pdf
Full Article (Word)	WJG-27-3705.docx
Manuscript File	61811_Auto_Edited-ZMG.docx
Answering Reviewers	61811-Answering reviewers.pdf
Audio Core Tip	61811-Audio core tip.m4a
Conflict-of-Interest Disclosure Form	61811-Conflict-of-interest statement.pdf
Copyright License Agreement	61811-Copyright license agreement.pdf
Peer-review Report	61811-Peer-review(s).pdf
Scientific Misconduct Check	61811-Bing-Wang JL-1.jpg
Scientific Misconduct Check	61811-Scientific misconduct check.pdf
Scientific Editor Work List	61811-Scientific editor work list.pdf
CrossCheck Report	61811-CrossCheck report.pdf