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Articles Published Processes
4/21/2021 5:56:26 AM | Browse: 484 | Download: 1158
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Received |
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2021-01-08 12:22 |
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Peer-Review Started |
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2021-01-08 12:23 |
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To Make the First Decision |
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Return for Revision |
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2021-02-11 01:58 |
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Revised |
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2021-02-14 04:42 |
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Second Decision |
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2021-03-24 12:29 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2021-03-25 04:00 |
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Articles in Press |
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2021-03-25 04:00 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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2021-04-06 03:23 |
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Typeset the Manuscript |
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2021-04-16 07:21 |
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Publish the Manuscript Online |
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2021-04-21 05:56 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Oncology |
| Manuscript Type |
Basic Study |
| Article Title |
Mitochondrial pathway of the lysine demethylase 5C inhibitor CPI-455 on the Eca-109 esophageal squamous cell carcinoma cell line
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Xiao-Jie Xue, Fei-Rong Li and Jing Yu |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Young Talents Project of Hubei Provincial Health Commission |
WJ2019H449 |
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| Corresponding Author |
Jing Yu, PhD, Doctor, Doctor, Department of Laboratory Medicine, Hubei Cancer Hospital, Tongji Medical College, Huazhong University of Science and Technology, No. 116 Zhuodaoquan South Road, Wuhan 430079, Hubei Province, China. yujings9774@sina.com.cn |
| Key Words |
Lysine-specific demethylase 5C; CPI-455; Esophageal squamous cell carcinoma; Caspase; P53 |
| Core Tip |
This study confirmed that CPI-455 inhibits esophageal squamous cell carcinoma Eca-109 cells proliferation, lysine-specific demethylase 5C played a role in esophageal squamous cell carcinoma cells proliferation and invasion, which may be partly associated with the p53, Bax, Caspase-9, and Caspase-3 expression. mitochondria-mediated intrinsic apoptotic signaling pathway by regulating the expression of related genes play an important role during the process of Eca-109 cell apoptosis induced by CPI-455. |
| Publish Date |
2021-04-21 05:56 |
| Citation |
Xue XJ, Li FR, Yu J. Mitochondrial pathway of the lysine demethylase 5C inhibitor CPI-455 on the Eca-109 esophageal squamous cell carcinoma cell line. World J Gastroenterol 2021; 27(16): 1805-1815 |
| URL |
https://www.wjgnet.com/1007-9327/full/v27/i16/1805.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v27.i16.1805 |
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