| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Oncology |
| Manuscript Type |
Clinical and Translational Research |
| Article Title |
Survival-associated alternative splicing events interact with immune microenvironment in stomach adenocarcinoma
|
| Manuscript Source |
Invited Manuscript |
| All Author List |
Zai-Sheng Ye, Miao Zheng, Qin-Ying Liu, Yi Zeng, Sheng-Hong Wei, Yi Wang, Zhi-Tao Lin, Chen Shu, Qiu-Hong Zheng and Lu-Chuan Chen |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Clinical Key Specialty Construction Program of China and Grants from the National Science Foundation Project of the Fujian Science and Technology Department |
2017J01264 |
| Foundation for Fujian Provincial Health Technology Project |
2019-ZQN-16 |
| National Clinical Key Specialty Construction Program of China and Grants from the National Science Foundation Project of the Fujian Science and Technology Department |
2018Y0015 |
| Foundation for Fujian Provincial Health Technology Project |
2019-CXB-9 |
| Foundation for Fujian Provincial Health Technology Project |
2019006 |
| Startup Fund for Scientific Research, Fujian Medical University |
2017Q1219 |
| Startup Fund for Scientific Research, Fujian Medical University |
2017Q1220 |
|
| Corresponding Author |
Lu-Chuan Chen, BM BCh, MD, Chief Doctor, Director, Surgical Oncologist, Teacher, Department of Gastrointestinal Surgical Oncology, Fujian Cancer Hospital & Fujian Medical University Cancer Hospital, Fuma Road420@, Jin an District, Fuzhou 350014, Fujian Province, China. luchuanchen@fjzlhospital.com |
| Key Words |
Stomach adenocarcinoma; Alternative splicing; Tumor microenvironment; Immune-related genes and pathways |
| Core Tip |
In this study, we performed a systematic analysis of prognostic splicing events in stomach adenocarcinoma (STAD), constructed an elevated Alternative splicing (AS)-signature prognostic model, and explored the association between AS and cancer immunity. The final overall survival-related AS events, differentially expressed immune-related genes, and the enriched pathways may play an important role in tumorigenesis in STAD; they deserve further study in clinical applications as diagnostic biomarkers and therapeutic targets. |
| Publish Date |
2021-05-27 09:41 |
| Citation |
Ye ZS, Zheng M, Liu QY, Zeng Y, Wei SH, Wang Y, Lin ZT, Shu C, Zheng QH, Chen LC. Survival-associated alternative splicing events interact with immune microenvironment in stomach adenocarcinoma. World J Gastroenterol 2021; 27(21): 2871-2894 |
| URL |
https://www.wjgnet.com/1007-9327/full/v27/i21/2871.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v27.i21.2871 |
