Publication Name	World Journal of Clinical Cases
Manuscript ID	62066
Country	China

Received	2020-12-28 01:25
Peer-Review Started	2020-12-28 01:27
To Make the First Decision
Return for Revision	2021-01-18 01:41
Revised	2021-01-25 07:14
Second Decision	2021-03-04 13:36
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2021-03-06 04:37
Articles in Press	2021-03-06 04:37
Publication Fee Transferred
Edit the Manuscript by Language Editor	2021-04-15 15:10
Typeset the Manuscript	2021-05-24 02:53
Publish the Manuscript Online	2021-05-26 09:58

ISSN	2307-8960 (online)
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Category	Gastroenterology & Hepatology
Manuscript Type	Retrospective Study
Article Title	Why MUC16 mutations lead to a better prognosis: A study based on The Cancer Genome Atlas gastric cancer cohort
Manuscript Source	Unsolicited Manuscript
All Author List	Yu-Jie Huang, Zhi-Fei Cao, Jie Wang, Jian Yang, Yi-Jun Wei, Yu-Chen Tang, Yin-Xiang Cheng, Jian Zhou and Zi-Xiang Zhang
ORCID	Author(s) ORCID Number Yu-Jie Huang http://orcid.org/0000-0003-4773-8515 Zhi-Fei Cao http://orcid.org/0000-0002-7940-6235 Jie Wang http://orcid.org/0000-0001-5621-0857 Jian Yang http://orcid.org/0000-0002-5573-2650 Yi-Jun Wei http://orcid.org/0000-0003-1711-5683 Yu-Chen Tang http://orcid.org/0000-0002-6123-3049 Yin-Xiang Cheng http://orcid.org/0000-0002-3032-5688 Jian Zhou http://orcid.org/0000-0002-0749-1354 Zi-Xiang Zhang http://orcid.org/0000-0001-9204-3873
Funding Agency and Grant Number	Funding Agency Grant Number National Natural Science Foundation of China 81902385 The Project of Suzhou People's Livelihood Science and Technology SYS2018037 The Project of Suzhou People's Livelihood Science and Technology SYS201739 The Six Talent Peaks Project in Jiangsu Province WSW-059 Postgraduate Research & Practice Innovation Program of Jiangsu Province SJCX20_1073 Medical Research Programs of Health Commission Foundation of Jiangsu Province H2019071 The Project of Medical Research of Jiangsu Province Y2018094 The Project of Medical Research of Jiangsu Province H2018056
Corresponding Author	Zi-Xiang Zhang, PhD, Associate Professor, Department of General Surgery, The First Affiliated Hospital of Soochow University, No. 188 Shizi Street, Suzhou 215006, Jiangsu Province, China. zixiangzhang@163.com
Key Words	Gastric cancer; MUC16 mutation; CA-125; Prognosis; The Cancer Genome Atlas; Gene Expression Omnibus
Core Tip	Our study utilized multi-omics data from The Cancer Genome Atlas, by analyzing these data, we found that the MUC16 mutations may activate the p53 pathway and DNA repair pathway on the one hand, on the other hand, the tumor microenvironment may be involved, with higher tumor killer cells and lower stromal score together building the unique tumor microenvironment of the mutation group.
Publish Date	2021-05-26 09:58
Citation	Huang YJ, Cao ZF, Wang J, Yang J, Wei YJ, Tang YC, Cheng YX, Zhou J, Zhang ZX. Why MUC16 mutations lead to a better prognosis: A study based on The Cancer Genome Atlas gastric cancer cohort. World J Clin Cases 2021; 9(17): 4143-4158
URL	https://www.wjgnet.com/2307-8960/full/v9/i17/4143.htm
DOI	https://dx.doi.org/10.12998/wjcc.v9.i17.4143

Full Article (PDF)	WJCC-9-4143.pdf
Full Article (Word)	WJCC-9-4143.docx
Manuscript File	62066_Auto_Edited_LM-Webster J-Clear.docx
Answering Reviewers	62066-Answering reviewers.pdf
Audio Core Tip	62066-Audio core tip.wav
Biostatistics Review Certificate	62066-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form	62066-Conflict-of-interest statement.pdf
Copyright License Agreement	62066-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	62066-Grant application form(s).pdf
Signed Informed Consent Form(s) or Document(s)	62066-Informed consent statement.pdf
Institutional Review Board Approval Form or Document	62066-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate	62066-Language certificate.pdf
Supplementary Material	62066-Supplementary material.pdf
Peer-review Report	62066-Peer-review(s).pdf
Scientific Misconduct Check	62066-Scientific misconduct check.pdf
Scientific Editor Work List	62066-Scientific editor work list.pdf