| ISSN |
2307-8960 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0 |
| Copyright |
© The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
|
| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
|
| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Retrospective Study |
| Article Title |
Why MUC16 mutations lead to a better prognosis: A study based on The Cancer Genome Atlas gastric cancer cohort
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Yu-Jie Huang, Zhi-Fei Cao, Jie Wang, Jian Yang, Yi-Jun Wei, Yu-Chen Tang, Yin-Xiang Cheng, Jian Zhou and Zi-Xiang Zhang |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Natural Science Foundation of China |
81902385 |
| The Project of Suzhou People's Livelihood Science and Technology |
SYS2018037 |
| The Project of Suzhou People's Livelihood Science and Technology |
SYS201739 |
| The Six Talent Peaks Project in Jiangsu Province |
WSW-059 |
| Postgraduate Research & Practice Innovation Program of Jiangsu Province |
SJCX20_1073 |
| Medical Research Programs of Health Commission Foundation of Jiangsu Province |
H2019071 |
| The Project of Medical Research of Jiangsu Province |
Y2018094 |
| The Project of Medical Research of Jiangsu Province |
H2018056 |
|
| Corresponding Author |
Zi-Xiang Zhang, PhD, Associate Professor, Department of General Surgery, The First Affiliated Hospital of Soochow University, No. 188 Shizi Street, Suzhou 215006, Jiangsu Province, China. zixiangzhang@163.com |
| Key Words |
Gastric cancer; MUC16 mutation; CA-125; Prognosis; The Cancer Genome Atlas; Gene Expression Omnibus |
| Core Tip |
Our study utilized multi-omics data from The Cancer Genome Atlas, by analyzing these data, we found that the MUC16 mutations may activate the p53 pathway and DNA repair pathway on the one hand, on the other hand, the tumor microenvironment may be involved, with higher tumor killer cells and lower stromal score together building the unique tumor microenvironment of the mutation group. |
| Publish Date |
2021-05-26 09:58 |
| Citation |
Huang YJ, Cao ZF, Wang J, Yang J, Wei YJ, Tang YC, Cheng YX, Zhou J, Zhang ZX. Why MUC16 mutations lead to a better prognosis: A study based on The Cancer Genome Atlas gastric cancer cohort. World J Clin Cases 2021; 9(17): 4143-4158 |
| URL |
https://www.wjgnet.com/2307-8960/full/v9/i17/4143.htm |
| DOI |
https://dx.doi.org/10.12998/wjcc.v9.i17.4143 |
