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Articles Published Processes
6/18/2021 5:06:16 AM | Browse: 393 | Download: 889
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Received |
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2021-02-04 02:23 |
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Peer-Review Started |
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2021-02-04 02:28 |
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To Make the First Decision |
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Return for Revision |
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2021-02-24 04:06 |
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Revised |
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2021-03-05 09:15 |
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Second Decision |
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2021-05-19 08:48 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Company Editor-in-Chief |
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2021-05-19 11:59 |
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Articles in Press |
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2021-05-19 11:59 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2021-06-10 00:50 |
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Publish the Manuscript Online |
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2021-06-18 05:06 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Basic Study |
| Article Title |
Conditioned secretome of adipose-derived stem cells improves dextran sulfate sodium-induced colitis in mice
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Seunghun Lee, Jeonghoon Heo, Eun-Kyung Ahn, Jae Hyun Kim, Young-Ho Kim, Hee-Kyung Chang, Sang-Joon Lee, Jongsik Kim and Seun-Ja Park |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Research Foundation of Korea (NRF) grants funded by the Korea government (MSIT) |
2017R1A2B2011956 |
| National Research Foundation of Korea (NRF) grants funded by the Korea government (MSIT) |
2019R1F1A1061453 |
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| Corresponding Author |
Seun-Ja Park, MD, PhD, Professor, Department of Gastroenterology, Kosin University College of Medicine, 262 Gamcheon-ro, Seogu, Busan 49267, South Korea. parksj@kosinmed.or.kr |
| Key Words |
Adipose-derived stem cells; Conditioned secretome; Cytokines; Interleukin-6; Colitis; Regeneration |
| Core Tip |
The therapeutic ability of mesenchymal stem cells (MSCs) is mostly mediated by their paracrine effects. Cell free therapy using MSCs secretome could be more promising strategy than stem cells based therapy. The present study demonstrates that the conditioned secretome of adipose–derived stem cells (ADSCs) has more efficient effects for improving acute colitis in dextran sulfate-sodium-induced mouse model. The effects by the conditioned secretome of ADSCs were mediated by suppression of interleukin (IL)-6 mRNA synthesis in colon tissue and serum IL-6 protein levels, which suggests that the stem cell secretome may have efficient therapeutic potential for incurable inflammatory bowel diseases. |
| Publish Date |
2021-06-18 05:06 |
| Citation |
Lee S, Heo J, Ahn EK, Kim JH, Kim YH, Chang HK, Lee SJ, Kim J, Park SJ. Conditioned secretome of adipose-derived stem cells improves dextran sulfate sodium-induced colitis in mice. World J Gastroenterol 2021; 27(23): 3342-3356 |
| URL |
https://www.wjgnet.com/1007-9327/full/v27/i23/3342.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v27.i23.3342 |
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