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Articles Published Processes
4/22/2021 12:14:43 PM | Browse: 530 | Download: 1164
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Received |
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2021-01-09 13:34 |
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Peer-Review Started |
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2021-01-09 13:36 |
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To Make the First Decision |
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Return for Revision |
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2021-01-24 04:07 |
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Revised |
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2021-02-04 20:36 |
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Second Decision |
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2021-03-09 13:25 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2021-03-10 05:26 |
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Articles in Press |
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2021-03-10 05:26 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2021-04-19 12:24 |
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Publish the Manuscript Online |
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2021-04-22 12:14 |
| ISSN |
2307-8960 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Case Report |
| Article Title |
Treatment of acute severe ulcerative colitis using accelerated infliximab regimen based on infliximab trough level: A case report
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Ana Lorena Sousa de Vasconcelos Garate, Thiara Barcelos Rocha, Luciana Rocha Almeida, Rodrigo Quera, Jaqueline Ribeiro Barros, Julio Pinheiro Baima, Rogerio Saad-Hossne and Ligia Yukie Sassaki |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Ligia Yukie Sassaki, MD, PhD, Academic Research, Assistant Professor, Department of Internal Medicine, São Paulo State University (Unesp), Medical School, Av. Professor Mário Rubens Guimarães Montenegro, s/n, Botucatu 18618687, São Paulo, Brazil. ligia.sassaki@unesp.br |
| Key Words |
Infliximab; Acute severe ulcerative colitis; Toxic megacolon; Ulcerative colitis; Inflammatory bowel disease; Case report |
| Core Tip |
Acute severe ulcerative colitis (ASUC) is associated with high circulating levels of tumor necrosis factor-alpha, due to intense inflammation and faster stool clearance of the anti-tumor necrosis factor drug. Consequently, these patients may need higher doses or more frequent administrations of infliximab. A young patient with a recent diagnosis of ulcerative colitis presenting with ASUC associated with megacolon, was successfully treated with intravenous corticosteroids and an accelerated infliximab regimen, based on the serum levels of the medication. Despite the favorable outcome in the case reported, longitudinal studies are necessary to define the best therapeutic drug monitoring and treatment regimen for these patients. |
| Publish Date |
2021-04-22 12:14 |
| Citation |
Garate ALSV, Rocha TB, Almeida LR, Quera R, Barros JR, Baima JP, Saad-Hossne R, Sassaki LY. Treatment of acute severe ulcerative colitis using accelerated infliximab regimen based on infliximab trough level: A case report. World J Clin Cases 2021; 9(13): 3119-3226 |
| URL |
https://www.wjgnet.com/2307-8960/full/v9/i13/3219.htm |
| DOI |
https://dx.doi.org/10.12998/wjcc.v9.i13.3219 |
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