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Articles Published Processes
5/13/2021 10:05:39 AM | Browse: 585 | Download: 1334
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Received |
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2021-01-16 14:48 |
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Peer-Review Started |
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2021-01-16 14:50 |
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To Make the First Decision |
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Return for Revision |
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2021-02-10 20:13 |
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Revised |
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2021-02-23 18:05 |
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Second Decision |
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2021-04-22 08:11 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2021-04-22 12:29 |
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Articles in Press |
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2021-04-22 12:29 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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2021-05-03 14:19 |
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Typeset the Manuscript |
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2021-05-11 10:57 |
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Publish the Manuscript Online |
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2021-05-13 10:05 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Infectious Diseases |
| Manuscript Type |
Observational Study |
| Article Title |
Effects of sepsis and its treatment measures on the structure of the intestinal flora of critical care patients
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Xiao-Juan Yang, Dan Liu, Hong-Yan Ren, Xiao-Ya Zhang, Jun Zhang and Xiao-Jun Yang |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Key Research and Development Program of China |
NO.2016YFD0400605 |
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| Corresponding Author |
Xiao-Jun Yang, MM, Chief Doctor, Professor, Department of Critical Care Medicine, General Hospital of Ningxia Medical University, No. 804 Shengli South Street, Xingqing District, Yinchuan 750004, Ningxia Hui Autonomous Region, China. yxjicu@163.com |
| Key Words |
Sepsis; Intestinal flora; 16S rRNA gene sequencing; Dynamic changes; Intestinal barrier index; Procalcitonin |
| Core Tip |
As the largest reservoir of bacteria and endotoxins in the body, the intestinal tract is regarded as the “engine” of sepsis and multiple organ dysfunction. Through 16S rRNA gene sequencing, we observed that intestinal flora disturbance occurs in sepsis patients. Notably, here, we reveal for the first time the intestinal flora dynamic changes in sepsis patients during treatment. We found that the abundance of some intestinal bacteria in sepsis patients significantly correlates with infection- and intestinal barrier-related clinical indicators. These findings add to the understanding of the intestinal flora in sepsis, providing a basis for the reversal of dysbiosis. |
| Publish Date |
2021-05-13 10:05 |
| Citation |
Yang XJ, Liu D, Ren HY, Zhang XY, Zhang J, Yang XJ. Effects of sepsis and its treatment measures on the structure of the intestinal flora of critical care patients. World J Gastroenterol 2021;27(19): 2376-2393 |
| URL |
https://www.wjgnet.com/1007-9327/full/v27/i19/2376.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v27.i19.2376 |
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