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Articles Published Processes
6/25/2021 9:46:23 AM | Browse: 429 | Download: 903
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Received |
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2021-01-15 08:31 |
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Peer-Review Started |
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2021-01-15 08:33 |
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To Make the First Decision |
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Return for Revision |
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2021-03-29 05:38 |
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Revised |
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2021-04-09 03:31 |
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Second Decision |
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2021-05-27 07:00 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Company Editor-in-Chief |
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2021-05-27 09:47 |
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Articles in Press |
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2021-05-27 09:47 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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2021-06-01 15:09 |
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Typeset the Manuscript |
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2021-06-22 03:43 |
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Publish the Manuscript Online |
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2021-06-25 09:46 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Basic Study |
| Article Title |
Fasudil prevents liver fibrosis via activating natural killer cells and suppressing hepatic stellate cells
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Qiu-Ju Han, Yong-Liang Mu, Hua-Jun Zhao, Rong-Rong Zhao, Quan-Juan Guo, Yu-Hang Su and Jian Zhang |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Natural Science Foundation of China |
81972694 |
| National Natural Science Foundation of China |
81972686 |
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| Corresponding Author |
Jian Zhang, PhD, Dean, Professor, Institute of Immunopharmaceutical Sciences, School of Pharmaceutical Sciences, Shandong University, No. 44 Wenhua West Road, Jinan 250012, Shandong , China. zhangj65@sdu.edu.cn |
| Key Words |
Liver fibrosis; Natural killer cells; Fasudil; Hepatic stellate cells |
| Core Tip |
Liver fibrosis is caused by inflammation and characterized by accumulation of extracellular matrix, there is no clinically safe and efficient drug to treat liver fibrosis. Fasudil treatment inhibits liver injury and liver fibrosis in vivo, it prevents liver fibrosis via activating natural killer cells but suppressing hepatic stellate cells in Thioacetamide-induced model. As a drug used clinically, these provide a feasible solution for clinical treatment of liver fibrosis. |
| Publish Date |
2021-06-25 09:46 |
| Citation |
Han QJ, Mu YL, Zhao HJ, Zhao RR, Guo QJ, Su YH, Zhang J. Fasudil prevents liver fibrosis via activating natural killer cells and suppressing hepatic stellate cells. World J Gastroenterol 2021; 27(24): 3581-3594 |
| URL |
https://www.wjgnet.com/1007-9327/full/v27/i24/3581.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v27.i24.3581 |
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