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Articles Published Processes
4/9/2021 5:27:04 AM | Browse: 575 | Download: 911
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Received |
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2021-01-16 12:39 |
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Peer-Review Started |
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2021-01-16 12:40 |
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To Make the First Decision |
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Return for Revision |
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2021-01-24 23:32 |
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Revised |
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2021-01-30 11:26 |
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Second Decision |
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2021-02-18 13:50 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2021-02-19 03:49 |
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Articles in Press |
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2021-02-19 03:49 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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2021-02-26 00:49 |
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Typeset the Manuscript |
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2021-03-12 02:00 |
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Publish the Manuscript Online |
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2021-04-09 05:27 |
| ISSN |
1948-9358 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Developmental Biology |
| Manuscript Type |
Review |
| Article Title |
Maternal obesity as a risk factor for developing diabetes in offspring: An epigenetic point of view
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Simon Lecoutre, Salwan Maqdasy and Christophe Breton |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Christophe Breton, PhD, Full Professor, U1283-UMR8199-EGID, University of Lille, Institut National de la Santé Et de la Recherche Médicale, Centre National de la Recherche Scientifique, CHU Lille, Institut Pasteur de Lille, Lille 59000, France. christophe.breton@univ-lille1.fr |
| Key Words |
Development; Epigenome; Obesity; Type 2 diabetes; Adipose tissue; Beta cells |
| Core Tip |
According to the developmental origin of health and disease concept, maternal obesity and neonatal accelerated growth predispose offspring to metabolic diseases. White adipose tissue and pancreatic β-cells are key targets of developmental programming, though the underlying mechanisms remain elusive. Human and rodent studies have contributed to decipher the role of epigenetic mechanisms in the transgenerational inheritance of obesity and type 2 diabetes. In this review, we discuss the current understanding of the link between obesogenic maternal nutritional environment, developmental epigenetic adipocyte and β-cells remodeling and predisposition to obesity and type 2 diabetes later in life. |
| Publish Date |
2021-04-09 05:27 |
| Citation |
Lecoutre S, Maqdasy S, Breton C. Maternal obesity as a risk factor for developing diabetes in offspring: An epigenetic point of view. World J Diabetes 2021; 12(4): 366-382 |
| URL |
https://www.wjgnet.com/1948-9358/full/v12/i4/366.htm |
| DOI |
https://dx.doi.org/10.4239/wjd.v12.i4.366 |
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