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Articles Published Processes
6/24/2021 7:26:33 AM | Browse: 591 | Download: 1378
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Received |
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2021-01-30 06:42 |
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Peer-Review Started |
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2021-01-30 06:43 |
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First Decision by Editorial Office Director |
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2021-05-06 18:39 |
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Return for Revision |
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2021-05-06 18:39 |
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Revised |
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2021-05-10 10:34 |
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Publication Fee Transferred |
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Second Decision by Editor |
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2021-05-18 09:05 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2021-05-18 22:42 |
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Articles in Press |
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2021-05-18 22:42 |
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Edit the Manuscript by Language Editor |
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2021-05-22 18:49 |
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Typeset the Manuscript |
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2021-06-14 15:38 |
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Publish the Manuscript Online |
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2021-06-24 07:26 |
| ISSN |
2307-8960 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Pediatrics |
| Manuscript Type |
Case Report |
| Article Title |
Severe hyperbilirubinemia in a neonate with hereditary spherocytosis due to a de novo ankyrin mutation: A case report
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Jun-Fang Wang, Li Ma, Xiao-Hui Gong, Cheng Cai and Jing-Jing Sun |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Shanghai Jiao Tong University “Jiao Tong Star” Medical-Industrial Cross-Research Fund |
YG2019ZDA01 |
| Shanghai Key Clinical Specialty Project |
shslczdzk05705 |
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| Corresponding Author |
Jing-Jing Sun, MD, Chief Physician, Department of Neonatology, Shanghai Children’s Hospital, Shanghai Jiao Tong University, No. 355 Luding Road, Putuo District, Shanghai 200062, China. sunjj@shchildren.com.cn |
| Key Words |
Hereditary spherocytosis; Ankyrin; Neonate; Intractable neonatal jaundice; Case report |
| Core Tip |
Hereditary spherocytosis (HS) is a common type of hemolytic anemia caused by red cell membrane disorder. HS type 1 (HS1) typically results from mutations in ankyrin (ANK1). Newborns with HS1 usually only exhibit anemia and mild jaundice. This paper reports on a Chinese neonate who developed severe, intractable neonatal jaundice unrelated to immune-mediated hemolysis. The patient underwent two exchange transfusions and one plasmapheresis, which significantly reduced his extreme hyperbilirubinemia. Using trio clinical exome sequencing, we identified a de novo null heterozygous mutation in the patient's ANK1 gene: c.841C>T(p.Arg281Term), which resulted in the premature termination of ANK1 protein. |
| Publish Date |
2021-06-24 07:26 |
| Citation |
Wang JF, Ma L, Gong XH, Cai C, Sun JJ. Severe hyperbilirubinemia in a neonate with hereditary spherocytosis due to a de novo ankyrin mutation: A case report. World J Clin Cases 2021; 9(19): 5245-5251 |
| URL |
https://www.wjgnet.com/2307-8960/full/v9/i19/5245.htm |
| DOI |
https://dx.doi.org/10.12998/wjcc.v9.i19.5245 |
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