Publication Name	World Journal of Gastroenterology
Manuscript ID	6288
Country	Japan

Received	2013-10-11 21:29
Peer-Review Started	2013-10-12 16:28
To Make the First Decision	2014-01-09 18:05
Return for Revision	2014-01-16 22:42
Revised	2014-01-24 13:48
Second Decision	2014-03-13 16:17
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2014-03-13 16:35
Articles in Press
Publication Fee Transferred
Edit the Manuscript by Language Editor	2014-04-18 19:23
Typeset the Manuscript	2014-05-12 14:45
Publish the Manuscript Online	2014-06-06 16:55

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
Article Reprints	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Autobiography
Article Title	Effects of bile acids on cyclooxygenase-2 expression in a rat model of duodenoesophageal anastomosis
Manuscript Source	Invited Manuscript
All Author List	Naoki Hashimoto
Funding Agency and Grant Number
Corresponding Author	Naoki Hashimoto, MD, PhD, Department of Surgery, Kinki University, 377-2 Ohonohigashi, Osakasayama, Osaka 589-8511, Japan. gojigen000@gmail.com
Key Words	Bile acids; Cyclooxygenase-2; Prostaglandin E2; Esophageal cancer; Esophagoduodenal anastomosis
Core Tip	It is known that reflux of duodenal contents (bile acids) can induce mucosal injury, stimulate cell proliferation, and promote tumorigenesis. We examined the expression of cyclooxygenase-2 (COX-2) and prostaglandin E2 in rat esophageal lesions induced by reflux of duodenal contents. All animals underwent an esophagoduodenal anastomosis with total gastrectomy to elicit chronic esophagitis. We demonstrated that reflux of duodenal contents induces COX-2 and increases prostaglandin synthesis in dysplastic and cancer tissues. This result suggests a possible mechanism by which bile acids promote esophageal cancer.
Publish Date	2014-06-06 16:55
Citation	Hashimoto N. Effects of bile acids on cyclooxygenase-2 expression in a rat model of duodenoesophageal anastomosis. World J Gastroenterol 2014; 20(21): 6541-6546
URL	http://www.wjgnet.com/1007-9327/full/v20/i21/6541.htm
DOI	http://dx.doi.org/10.3748/wjg.v20.i21.6541

Full Article (PDF)	WJG-20-6541.pdf
Full Article (Word)	WJG-20-6541.doc
Manuscript File	6288-Review.docx
Answering Reviewers	6288-Answering reviewers.pdf
Copyright License Agreement	6288-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate	6288-Language certificate.pdf
Peer-review Report	6288-Peer review(s).pdf
Scientific Editor Work List	6288-Scientific editor work list.doc