| ISSN |
1948-5204 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Oncology |
| Manuscript Type |
Basic Study |
| Article Title |
Plasma MMP-2 and MMP-7 levels are elevated first month after surgery and may promote growth of residual metastases
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
HMC Shantha Kumara, Hiromichi Miyagaki, Sajith A Herath, Erica Pettke, Xiaohong Yan, Vesna Cekic and Richard L Whelan |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Thompson Family Foundation to the Division of Colon and Rectal Surgery, Department of Surgery, Mount Sinai West Hospital, New York |
|
|
| Corresponding Author |
Richard L Whelan, FACS, MD, N/A, N/A, Professor, Division of Colon and Rectal Surgery, Department of Surgery, Lenox Hill Hospital, Northwell Health, Suite 1B, 122 East, 76th Street, New York, NY 10028, United States. rwhelan1@northwell.edu |
| Key Words |
Effects of surgery; colorectal resection; colorectal cancer; Plasma MMP2 and MMP7 levels; Angiogenesis |
| Core Tip |
Our past studies have shown that the levels of 9 plasma proteins that play a role in angiogenesis have been shown to be elevated, vs baseline levels, for 2-5 wk after minimally invasive colorectal cancer resection (MICR). This group of proteins includes vascular endothelial-derived growth factor, placental growth factor, angiopoietin-2, soluble vascular adhesion molecule-1, monocyte chemo-attractant protein-1, chitinase 3-like-1, interleukin-8, CXCL16 and MMP-3 (matrix metalloproteinase-3). We have demonstrated that postoperative plasma from colorectal cancer (CRC) patients stimulates in vitro endothelial cell proliferation, migration, and invasion. This manuscript is to demonstrate that proangiogenic proteins, plasma MMP-2 and MMP-7 in CRC patients remain elevated for month after MICR. |
| Publish Date |
2021-08-14 11:08 |
| Citation |
Shantha Kumara H, Miyagaki H, Herath SA, Pettke E, Yan X, Cekic V, Whelan RL. Plasma MMP-2 and MMP-7 levels are elevated first month after surgery and may promote growth of residual metastases. World J Gastrointest Oncol 2021; 13(8): 879-892 |
| URL |
https://www.wjgnet.com/1948-5204/full/v13/i8/879.htm |
| DOI |
https://dx.doi.org/10.4251/wjgo.v13.i8.879 |
