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Articles Published Processes
4/9/2021 9:07:56 AM | Browse: 484 | Download: 1030
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Received |
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2021-01-21 07:04 |
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Peer-Review Started |
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2021-01-21 07:08 |
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To Make the First Decision |
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Return for Revision |
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2021-02-10 19:36 |
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Revised |
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2021-02-23 15:04 |
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Second Decision |
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2021-03-17 10:42 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2021-03-17 15:13 |
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Articles in Press |
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2021-03-17 15:13 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2021-04-02 10:51 |
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Publish the Manuscript Online |
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2021-04-09 09:07 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Infectious Diseases |
| Manuscript Type |
Review |
| Article Title |
Intracellular interferon signalling pathways as potential regulators of covalently closed circular DNA in the treatment of chronic hepatitis B
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Zhi Yi Goh, Ee Chee Ren and Hui Ling Ko |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Hui Ling Ko, PhD, Research Scientist, Singapore Immunology Network, Agency for Science, Technology and Research, 8A Biomedical Grove, #03-06 Immunos, Singapore 138648, Singapore. ko_huiling@immunol.a-star.edu.sg |
| Key Words |
Covalently closed circular DNA; Interferons; APOBECs; Epigenetic modification; Hepatitis B virus therapeutics |
| Core Tip |
Hepatitis B virus (HBV) infection remains an incurable disease affecting millions worldwide. Treatment with interferons (IFNs) can eliminate the virus by clearing its persistent genome, covalently closed circular DNA (cccDNA), from infected cells. However, its clinical efficacy is limited as HBV proteins antagonize IFN signalling. Other current therapeutics do not target cccDNA thus cannot eliminate HBV. Therefore, new drugs based on the knowledge of how IFNs cause cccDNA degradation and silencing, as well as insights into how HBV antagonizes IFN-mediated mechanisms are needed. This review summarizes what is known about these processes and highlights drugs and developing therapeutics targeted against them for HBV eradication. |
| Publish Date |
2021-04-09 09:07 |
| Citation |
Goh ZY, Ren EC, Ko HL. Intracellular interferon signalling pathways as potential regulators of cccDNA in the treatment of chronic hepatitis B. World J Gastroenterol 2021; 27(14): 1369-1391 |
| URL |
https://www.wjgnet.com/1007-9327/full/v27/i14/1369.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v27.i14.1369 |
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