Publication Name	World Journal of Clinical Cases
Manuscript ID	63098
Country	China

Received	2021-01-25 06:55
Peer-Review Started	2021-01-25 06:55
To Make the First Decision
Return for Revision	2021-03-25 05:53
Revised	2021-04-04 02:53
Second Decision	2021-05-07 06:55
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2021-05-07 11:53
Articles in Press	2021-05-07 11:53
Publication Fee Transferred
Edit the Manuscript by Language Editor	2021-05-13 00:03
Typeset the Manuscript	2021-05-21 01:24
Publish the Manuscript Online	2021-05-26 09:58

ISSN	2307-8960 (online)
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Category	Rehabilitation
Manuscript Type	Editorial
Article Title	Is it time to put traditional cold therapy in rehabilitation of soft-tissue injuries out to pasture?
Manuscript Source	Invited Manuscript
All Author List	Zi-Ru Wang and Guo-Xin Ni
ORCID	Author(s) ORCID Number Zi-Ru Wang http://orcid.org/0000-0003-4633-3161 Guo-Xin Ni http://orcid.org/0000-0001-9181-8155
Funding Agency and Grant Number
Corresponding Author	Guo-Xin Ni, MD, PhD, Chief Doctor, Dean, Professor, School of Sports Medicine and Rehabilitation, Beijing Sport University, Beijing 100084, China. guoxinni@fjmu.edu.cn
Key Words	Cryotherapy; Hyperbaric gaseous cryotherapy; Neurocryostimulation; Cold therapy; Soft tissue injury
Core Tip	Traditional cold therapy (e.g., topically icing the injured area) may not be helpful but rather act as a barrier to recovery process. A prolonged period of cold on the skin was reported to lead to a reduction of the blood flow, resulting in tissue death or even permanent nerve damage. Hyperbaric gaseous cryotherapy, also known as neurocryostimulation, has shown the ability to induce greater analgesic, anti-inflammatory, vasomotor, and muscle relaxing effects than other traditional cold application thus quicken recovery and heal following soft tissue injuries. More high quality level evidence is still needed to confirm the efficacy of hyperbaric gaseous cryotherapy about its clinical effects for soft-tissue injuries in the future, in order to find the optimal way to use it.
Publish Date	2021-05-26 09:58
Citation	Wang ZR, Ni GX. Is it time to put traditional cold therapy in rehabilitation of soft-tissue injuries out to pasture? World J Clin Cases 2021; 9(17): 4116-4122
URL	https://www.wjgnet.com/2307-8960/full/v9/i17/4116.htm
DOI	https://dx.doi.org/10.12998/wjcc.v9.i17.4116

Full Article (PDF)	WJCC-9-4116.pdf
Full Article (Word)	WJCC-9-4116.docx
Manuscript File	63098_Auto_Edited-JPY_WangTQ.docx
Answering Reviewers	63098-Answering reviewers.pdf
Audio Core Tip	63098-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	63098-Conflict-of-interest statement.pdf
Copyright License Agreement	63098-Copyright license agreement.pdf
Non-Native Speakers of English Editing Certificate	63098-Language certificate.pdf
Peer-review Report	63098-Peer-review(s).pdf
Scientific Misconduct Check	63098-Bing-Liu M-1.png
Scientific Misconduct Check	63098-Scientific misconduct check.pdf
Scientific Editor Work List	63098-Scientific editor work list.pdf
CrossCheck Report	63098-CrossCheck report.pdf