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Articles Published Processes
4/14/2021 7:32:38 AM | Browse: 712 | Download: 907
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Received |
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2021-01-28 16:21 |
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Peer-Review Started |
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2021-01-28 16:24 |
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To Make the First Decision |
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Return for Revision |
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2021-02-24 05:18 |
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Revised |
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2021-03-05 15:29 |
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Second Decision |
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2021-03-29 10:12 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2021-03-30 03:36 |
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Articles in Press |
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2021-03-30 03:36 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2021-04-13 00:14 |
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Publish the Manuscript Online |
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2021-04-14 07:32 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Oncology |
| Manuscript Type |
Basic Study |
| Article Title |
Effects of CXCL12 isoforms in a pancreatic pre-tumour cellular model: Microarray analysis
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Monia Cecati, Matteo Giulietti, Alessandra Righetti, Berina Sabanovic and Francesco Piva |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Fondazione Cariverona |
2017.0570 |
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| Corresponding Author |
Matteo Giulietti, PhD, Academic Research, Department of Specialistic Clinical and Odontostomatological Sciences, Polytechnic University of Marche, Via Brecce Bianche, Ancona 60126, Italy. m.giulietti@univpm.it |
| Key Words |
CXCL12; Splicing isoforms; Pancreatic cancer; Microarray; Migration; Wound healing assay |
| Core Tip |
In the microenvironment of pancreatic ductal adenocarcinoma (PDAC), stromal cells release different extracellular components, including CXCL12, in order to communicate with cancer cells. Here, we investigated the specific role of α, β, and γ CXCL12 splicing isoforms in PDAC onset, by using a pre-tumour model. Microarray analysis suggested a role of CXCL12 in cell migration, and wound healing assays confirmed this hypothesis. In particular, γ isoform showed the highest promotion of migration. Our results shed light on the molecular basis of PDAC onset and progression. |
| Publish Date |
2021-04-14 07:32 |
| Citation |
Cecati M, Giulietti M, Righetti A, Sabanovic B, Piva F. Effects of CXCL12 isoforms in a pancreatic pre-tumour cellular model: Microarray analysis. World J Gastroenterol 2021; 27(15): 1616-1629 |
| URL |
https://www.wjgnet.com/1007-9327/full/v27/i15/1616.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v27.i15.1616 |
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