Publication Name	World Journal of Gastroenterology
Manuscript ID	6338
Country	France

Received	2013-10-13 23:38
Peer-Review Started	2013-10-14 09:08
To Make the First Decision	2013-12-16 17:33
Return for Revision	2013-12-17 19:36
Revised	2014-01-26 01:50
Second Decision	2014-03-19 13:52
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2014-03-19 15:17
Articles in Press
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2014-03-31 15:27
Publish the Manuscript Online	2014-04-17 13:27

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
Article Reprints	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Topic Highlights
Article Title	Hallmarks in colorectal cancer: Angiogenesis and cancer stem-like cells
Manuscript Source	Invited Manuscript
All Author List	Muriel Mathonnet, Aurelie Perraud, Niki Christou, Hussein Akil, Carole Melin, Serge Battu, Marie-Odile Jauberteau and Yves Denizot
Funding Agency and Grant Number	Funding Agency Grant Number University of Limoges, Limoges University Hospital, La Ligue Contre le Cancer and the Région Limousin, which was given financial by the Comité Orientation Recherche Cancer to Perraud A, Christou N and Akil H
Corresponding Author	Muriel Mathonnet, MD, PhD, Professor of Digestive Surgery, Department of Digestive Surgery, Limoges University Hospital, 2 Ave Martin Luther King, 87042 Limoges, France. mathonnet@unilim.fr
Key Words	Colon cancer; Stem cell; Cancer stem-like cell; Tumor-initiating cell; Microenvironment
Core Tip	Recent progress in the therapeutic treatment of colorectal cancer has resulted from targeting the hallmark stem cell-like properties of tumor cells. The survival of colorectal cancer patients has been significantly prolonged with bevacizumab, which inhibits angiogenesis providing the proliferative conditions for tumor cell growth. Personalized therapeutic approaches, centered on the angiogenic and proliferative properties of cancerous cells, could improve patient survival and decrease adverse effects induced by unnecessary chemotherapy.
Publish Date	2014-04-17 13:27
Citation	Mathonnet M, Perraud A, Christou N, Akil H, Melin C, Battu S, Jauberteau MO, Denizot Y. Hallmarks in colorectal cancer: Angiogenesis and cancer stem-like cells. World J Gastroenterol 2014; 20(15): 4189-4196
URL	http://www.wjgnet.com/1007-9327/full/v20/i15/4189.htm
DOI	http://dx.doi.org/10.3748/wjg.v20.i15.4189

Full Article (PDF)	WJG-20-4189.pdf
Full Article (Word)	WJG-20-4189.doc
Manuscript File	6338-Review.docx
Answering Reviewers	6338-Answering reviewers.pdf
Copyright License Agreement	6338-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate	6338-Language certificate.pdf
Peer-review Report	6338-Peer review(s).pdf
Scientific Editor Work List	6338-Scientific editor work list.doc