Publication Name	World Journal of Gastroenterology
Manuscript ID	63552
Country	Australia

Received	2021-01-29 04:41
Peer-Review Started	2021-01-29 04:47
To Make the First Decision
Return for Revision	2021-05-02 00:23
Revised	2021-05-14 02:30
Second Decision	2021-07-21 03:32
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2021-07-21 07:00
Articles in Press	2021-07-21 07:00
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2021-07-27 06:59
Publish the Manuscript Online	2021-08-04 07:56

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
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Category	Gastroenterology & Hepatology
Manuscript Type	Minireviews
Article Title	Impact of modern antiviral therapy of chronic hepatitis B and C on clinical outcomes of liver disease
Manuscript Source	Invited Manuscript
All Author List	Tiffany Khoo, Danielle Lam and John K Olynyk
ORCID	Author(s) ORCID Number Tiffany Khoo http://orcid.org/0000-0003-2654-843X Danielle Lam http://orcid.org/0000-0002-2975-0839 John K Olynyk http://orcid.org/0000-0003-0417-3411
Funding Agency and Grant Number
Corresponding Author	John K Olynyk, FAASLD, AGAF, FRACP, MBBS, MD, Professor, Department of Gastroenterology and Hepatology, Fiona Stanley Hospital, 11 Robin Warren Drive, Murdoch 6150, Australia. john.olynyk@health.wa.gov.au
Key Words	Hepatitis B; Hepatitis C; Nucleotide analogues; Directly acting antiviral therapy; Clinical outcomes; Liver disease
Core Tip	Hepatitis B and C infection contribute significantly to the global burden of liver disease. With the introduction of modern antiviral therapy, there is now an effective curative treatment for hepatitis C and potent suppressive antiviral therapy for hepatitis B. Antiviral therapy has had a positive impact on liver disease by reducing hospitalisation rates and hence, cost to global health systems. Rates of decompensation, hepatocellular carcinoma and need for transplantation have all been lowered. This review article assesses the literature and summarises the impact of modern antiviral therapy of chronic hepatitis B and C on clinical outcomes from liver disease.
Publish Date	2021-08-04 07:56
Citation	Khoo T, Lam D, Olynyk JK. Impact of modern antiviral therapy of chronic hepatitis B and C on clinical outcomes of liver disease. World J Gastroenterol 2021; 27(29): 4831-4845
URL	https://www.wjgnet.com/1007-9327/full/v27/i29/4831.htm
DOI	https://dx.doi.org/10.3748/wjg.v27.i29.4831

Full Article (PDF)	WJG-27-4831.pdf
Full Article (Word)	WJG-27-4831.docx
Manuscript File	63552_Auto_Edited-JPY.docx
Answering Reviewers	63552-Answering reviewers.pdf
Audio Core Tip	63552-Audio core tip.m4a
Conflict-of-Interest Disclosure Form	63552-Conflict-of-interest statement.pdf
Copyright License Agreement	63552-Copyright license agreement.pdf
Peer-review Report	63552-Peer-review(s).pdf
Scientific Misconduct Check	63552-Scientific misconduct check.pdf
Scientific Editor Work List	63552-Scientific editor work list.pdf
CrossCheck Report	63552-CrossCheck report.pdf