Publication Name	World Journal of Gastroenterology
Manuscript ID	6369
Country	Italy

Received	2013-10-15 13:11
Peer-Review Started	2013-10-16 11:35
To Make the First Decision	2013-11-12 17:59
Return for Revision	2013-11-14 16:15
Revised	2014-02-24 04:37
Second Decision	2014-05-26 16:18
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2014-05-26 16:36
Articles in Press	2014-05-26 17:40
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2014-07-11 14:59
Publish the Manuscript Online	2014-07-26 13:36

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
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Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Pediatrics
Manuscript Type	Topic Highlights
Article Title	Polymorphisms in the IFNL3/IL28B gene and hepatitis C: From adults to children
Manuscript Source	Invited Manuscript
All Author List	Giuseppe Indolfi, Chiara Azzari and Massimo Resti
Funding Agency and Grant Number
Corresponding Author	Dr. Giuseppe Indolfi, Paediatric and Liver Unit, Meyer Children’s University Hospital of Florence, Viale Pieraccini 34, I-50139 Firenze, Italy. g.indolfi@meyer.it
Key Words	Hepatitis C virus; Children; Interferon L3; IL28B; Interferon-?; Treatment; Virological response
Core Tip	Single nucleotide polymorphisms in the interferon L3 (IFNL3) gene have been associated with both spontaneous and treatment-induced clearance of hepatitis C virus in children. Data from adult studies suggest a role of IFNL3 testing in the decision-making process of whether to treat a patient, the use of two or three drugs and whether the standard duration of treatment or a shorter duration should be proposed. These options are attractive if applicable to children. While waiting for the approval of new interferon-free regimens, paediatric collaborative studies to evaluate the possible role of genetic polymorphisms of IFNL3 as pre-treatment and on-treatment predictors of response, alone or together with other predictors, are highly needed.
Publish Date	2014-07-26 13:36
Citation	Indolfi G, Azzari C, Resti M. Polymorphisms in the IFNL3/IL28B gene and hepatitis C: From adults to children. World J Gastroenterol 2014; 20(28): 9245-9252
URL	http://www.wjgnet.com/1007-9327/full/v20/i28/9245.htm
DOI	http://dx.doi.org/10.3748/wjg.v20.i28.9245

Full Article (PDF)	WJG-20-9245.pdf
Full Article (Word)	WJG-20-9245.doc
Manuscript File	6369-Review.docx
Answering Reviewers	6369-Answering reviewers.pdf
Copyright License Agreement	6369-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate	6369-Language certificate.pdf
Peer-review Report	6369-Peer review(s).pdf
Scientific Misconduct Check	6369-CrossCheck.jpg
Scientific Editor Work List	6369-Scientific editor work list.pdf