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Articles Published Processes
11/19/2021 11:15:33 AM | Browse: 564 | Download: 1225
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Received |
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2021-04-19 11:39 |
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Peer-Review Started |
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2021-04-19 11:42 |
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To Make the First Decision |
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Return for Revision |
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2021-06-23 02:58 |
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Revised |
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2021-07-20 13:12 |
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Second Decision |
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2021-11-02 03:56 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2021-11-03 01:13 |
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Articles in Press |
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2021-11-03 01:13 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2021-11-16 15:01 |
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Publish the Manuscript Online |
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2021-11-19 11:15 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Prospective Study |
| Article Title |
Immunoglobulin G in non-alcoholic steatohepatitis predicts clinical outcome: A prospective multi-centre cohort study
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Marianne Anastasia De Roza, Mehul Lamba, George Boon-Bee Goh, Johnathan Huey-Ming Lum, Mark Chang-Chuen Cheah and Jing Hieng Jeffrey Ngu |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Jing Hieng Jeffrey Ngu, FRACP, PhD, Academic Research, Consultant Physician-Scientist, Doctor, Doctor, Department of Gastroenterology and Hepatology, Christchurch Hospital, Riccarton Avenue, Christchurch 8011, New Zealand. jeffrey.ngu@cdhb.health.nz |
| Key Words |
Non-alcoholic fatty liver disease; Non-alcoholic steatohepatitis; Immunoglobulin G; Autoantibodies; Mortality; Hepatic decompensation |
| Core Tip |
Autoantibodies such as anti-nuclear antibody (ANA) and anti-smooth-muscle antibody (ASMA) can be present in up to 20%-30% of patients with non-alcoholic steatohepatitis (NASH). However, clinical significance is not well studied and there is no published data on the impact of immunoglobulin G (IgG) and plasma cells on hepatic decompensation and mortality outcomes. Our study found that elevated IgG but not ANA, ASMA or plasma cells is associated with higher risk of mortality, including liver related death, as well as increased risk of hepatic decompensation events. Patients with IgG positive NASH should hence be identified early and monitored closely as they are at higher risk of poorer clinical outcomes. |
| Publish Date |
2021-11-19 11:15 |
| Citation |
De Roza MA, Lamba M, Goh GBB, Lum JHM, Cheah MCC, Ngu JHJ. Immunoglobulin G in non-alcoholic steatohepatitis predicts clinical outcome: A prospective multi-centre cohort study. World J Gastroenterol 2021; 27(43): 7563-7571 |
| URL |
https://www.wjgnet.com/1007-9327/full/v27/i43/7563.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v27.i43.7563 |
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