Publication Name	World Journal of Stem Cells
Manuscript ID	63802
Country	Brazil

Received	2021-02-05 16:37
Peer-Review Started	2021-02-05 16:39
To Make the First Decision
Return for Revision	2021-03-17 01:22
Revised	2021-03-29 21:33
Second Decision	2021-06-04 08:34
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2021-06-04 09:13
Articles in Press	2021-06-04 09:13
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2021-06-23 09:42
Publish the Manuscript Online	2021-06-26 07:48

ISSN	1948-0210 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved.
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Category	Orthopedics
Manuscript Type	Basic Study
Article Title	Chondrogenic potential of mesenchymal stem cells from horses using a magnetic 3D cell culture system
Manuscript Source	Invited Manuscript
All Author List	Joice Fülber, Fernanda R Agreste, Sarah R T Seidel, Eric D P Sotelo, Ângela P Barbosa, Yara M Michelacci and Raquel Y A Baccarin
ORCID	Author(s) ORCID Number Joice Fülber http://orcid.org/0000-0001-8989-6779 Fernanda R Agreste http://orcid.org/0000-0003-3106-8967 Sarah R T Seidel http://orcid.org/0000-0002-0808-6887 Eric D P Sotelo http://orcid.org/0000-0002-1938-4521 Ângela P Barbosa http://orcid.org/0000-0002-1163-9884 Yara M Michelacci http://orcid.org/0000-0001-8721-0251 Raquel Y A Baccarin http://orcid.org/0000-0001-9730-0840
Funding Agency and Grant Number	Funding Agency Grant Number Fundação Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES), Brazil 001
Corresponding Author	Joice Fülber, PhD, Postdoc, Departamento de Clínica Médica, Medicina Veterinária e Zootecnia, Universidade de São Paulo, Av. Prof. Dr. Orlando Marques de Paiva, 87 Cidade Universitária, São Paulo 05506-270, Brazil. jfulber@usp.br
Key Words	Cellular therapy; Chondrocytes; Aggrecan; Keratan sulfate
Core Tip	As a method no yet studied in equine chondrocytes, chondrogenic differentiation was performed in three-dimensional plate culture, using technology with biocompatible nanoparticles consisting of gold, iron oxide and poly-L-lysine, forming microspheroids. It has been shown that this technique is advantageous, as it allows for aggregation and a lower number of cells, ensuring high cell density, providing an adequate microenvironment for the differentiation and phenotypic expression of chondrocytes.
Publish Date	2021-06-26 07:48
Citation	Fülber J, Agreste FR, Seidel SRT, Sotelo EDP, Barbosa ÂP, Michelacci YM, Baccarin RYA. Chondrogenic potential of mesenchymal stem cells from horses using a magnetic 3D cell culture system. World J Stem Cells 2021; 13(6): 645-658
URL	https://www.wjgnet.com/1948-0210/full/v13/i6/645.htm
DOI	https://dx.doi.org/10.4252/wjsc.v13.i6.645

Full Article (PDF)	WJSC-13-645.pdf
Full Article (Word)	WJSC-13-645.docx
The ARRIVE Guidelines	63802-The-ARRIVE-Guidelines-revision.pdf
Manuscript File	63802_Auto_Edited-ZMG.docx
Answering Reviewers	63802-Answering reviewers.pdf
Audio Core Tip	63802_Audio core tip.mp4
Biostatistics Review Certificate	63802-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form	63802-Conflict-of-interest statement.pdf
Copyright License Agreement	63802-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	63802-Grant application form(s).pdf
Institutional Animal Care and Use Committee Approval Form or Document	63802-Institutional animal care and use committee statement.pdf
Non-Native Speakers of English Editing Certificate	63802-Language certificate.pdf
Peer-review Report	63802-Peer-review(s).pdf
Scientific Misconduct Check	63802-Bing Liu M-1.png
Scientific Misconduct Check	63802-Bing Liu M-2.png
Scientific Misconduct Check	63802-Scientific misconduct check.pdf
Scientific Editor Work List	63802-Scientific editor work list.pdf
CrossCheck Report	63802-CrossCheck report.pdf