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Articles Published Processes
7/12/2021 5:45:28 AM | Browse: 525 | Download: 989
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Received |
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2021-02-03 15:27 |
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Peer-Review Started |
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2021-02-03 15:44 |
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To Make the First Decision |
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Return for Revision |
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2021-03-01 00:52 |
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Revised |
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2021-04-16 18:48 |
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Second Decision |
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2021-06-16 13:22 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2021-06-16 13:54 |
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Articles in Press |
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2021-06-16 13:54 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2021-06-27 14:27 |
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Publish the Manuscript Online |
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2021-07-12 05:45 |
| ISSN |
1948-9358 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Immunology |
| Manuscript Type |
Review |
| Article Title |
Immunometabolic bases of type 2 diabetes in the severity of COVID-19
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Rebeca Viurcos-Sanabria and Galileo Escobedo |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Fondo Sectorial de Investigación para la Educación-CONACYT-México |
CB-2016-01-286209 |
| Fondo Sectorial de Investigación y Desarrollo en Salud y Seguridad Social SS/IMSS/ISSSTE/CONACYT-México |
SALUD-2017-02-290345 |
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| Corresponding Author |
Galileo Escobedo, PhD, Full Professor, Laboratorio de Proteómica, Dirección de Investigación, Hospital General de Mexico “Dr. Eduardo Liceaga”, Dr. Balmis 148, Mexico City 06720, Mexico. gescobedog@msn.com |
| Key Words |
COVID-19; SARS-CoV-2; Type 2 Diabetes; Inflammation; Hyperglycemia; Prothrombotic state |
| Core Tip |
Type 2 diabetes (T2D) acts in synergy with severe acute respiratory syndrome coronavirus-2 infection to increase the progression, severity, and mortality of coronavirus disease 2019 (COVID-19). Thus, the immunometabolic bases of the main etiological factors of T2D that contribute to the severity of COVID-19 should be studied. Here, we discuss the molecular mechanisms by which immune cells, hyperglycemia, hyperinsulinemia, loss of pancreatic β-cell mass, insulin resistance, advanced glycation end products, endothelial dysfunction, and prothrombotic state contribute to the severity of COVID-19. The syndemic between COVID-19 and T2D has challenged our ability to identify patients with high mortality risk based on scientific evidence. |
| Publish Date |
2021-07-12 05:45 |
| Citation |
Viurcos-Sanabria R, Escobedo G. Immunometabolic bases of type 2 diabetes in the severity of COVID-19. World J Diabetes 2021; 12(7): 1026-1041 |
| URL |
https://www.wjgnet.com/1948-9358/full/v12/i7/1026.htm |
| DOI |
https://dx.doi.org/10.4239/wjd.v12.i7.1026 |
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