| ISSN |
1948-0210 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
|
| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
|
| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Medicine, Research & Experimental |
| Manuscript Type |
Review |
| Article Title |
Exosomal microRNAs from mesenchymal stem/stromal cells: Biology and applications in neuroprotection
|
| Manuscript Source |
Invited Manuscript |
| All Author List |
Aida Nasirishargh, Priyadarsini Kumar, Lalithasri Ramasubramanian, Kaitlin Clark, Dake Hao, Sabrina V Lazar and Aijun Wang |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Institute on Aging of the National Institutes of Health through the UC Davis Alzheimer's Disease Center Pilot Program |
5R01NS100761-02 |
| National Institute on Aging of the National Institutes of Health through the UC Davis Alzheimer's Disease Center Pilot Program |
1R01NS115860-01A1 |
| Shriners Hospitals for Children Research Grants |
85108-NCA-19 |
| Shriners Hospitals for Children Research Grants |
85135-NCA-21 |
| Shriners Hospitals for Children Postdoctoral Fellowship |
84705-NCA-19 |
|
| Corresponding Author |
Aijun Wang, PhD, Associate Professor, Director, Surgical Bioengineering Laboratory, Department of Surgery, University of California, Davis School of Medicine, 4625 2nd Ave., Room 3005, Sacramento, CA 95817, United States. aawang@ucdavis.edu |
| Key Words |
Mesenchymal stromal cells; Mesenchymal stromal cell-derived exosomes; Exosomal microRNAs; Neuroprotective effect |
| Core Tip |
Mesenchymal stem/stromal cells (MSCs) are multipotent stem cells, which, due to their high availability and their reparative abilities, have been developed as therapeutic agents for various neurological diseases. MSC-derived exosomes have been receiving increased attention for their therapeutic capacity and low adverse effects. This review summarizes recent research on the neuroprotective effects of selected MSC-derived exosomal microRNAs (miRNAs) and provides an overview of their application potential in different neurological disorder disease models. It also discusses practical bioengineering approaches for isolating MSC-derived exosomes, manipulating their miRNA cargos, and improving their therapeutic abilities. |
| Publish Date |
2021-07-23 13:30 |
| Citation |
Nasirishargh A, Kumar P, Ramasubramanian L, Clark K, Hao D, Lazar SL, Wang AJ. Exosomal microRNAs from mesenchymal stem/stromal cells: Biology and applications in neuroprotection. World J Stem Cells 2021; 13(7): 776-794 |
| URL |
https://www.wjgnet.com/1948-0210/full/v13/i7/776.htm |
| DOI |
https://dx.doi.org/10.4252/wjsc.v13.i7.776 |
