| ISSN |
1948-0210 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Medicine, Research & Experimental |
| Manuscript Type |
Review |
| Article Title |
Exosomal microRNAs from mesenchymal stem/stromal cells: Biology and applications in neuroprotection
|
| Manuscript Source |
Invited Manuscript |
| All Author List |
Aida Nasirishargh, Priyadarsini Kumar, Lalithasri Ramasubramanian, Kaitlin Clark, Dake Hao, Sabrina V Lazar and Aijun Wang |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Institute on Aging of the National Institutes of Health through the UC Davis Alzheimer's Disease Center Pilot Program |
5R01NS100761-02 |
| National Institute on Aging of the National Institutes of Health through the UC Davis Alzheimer's Disease Center Pilot Program |
1R01NS115860-01A1 |
| Shriners Hospitals for Children Research Grants |
85108-NCA-19 |
| Shriners Hospitals for Children Research Grants |
85135-NCA-21 |
| Shriners Hospitals for Children Postdoctoral Fellowship |
84705-NCA-19 |
|
| Corresponding Author |
Aijun Wang, PhD, Associate Professor, Director, Director, Surgical Bioengineering Laboratory, Department of Surgery, University of California, Davis School of Medicine, 4625 2nd Ave., Room 3005, Sacramento, CA 95817, United States. aawang@ucdavis.edu |
| Key Words |
Mesenchymal stromal cells; Mesenchymal stromal cell-derived exosomes; Exosomal microRNAs; Neuroprotective effect |
| Core Tip |
Mesenchymal stem/stromal cells (MSCs) are multipotent stem cells, which, due to their high availability and their reparative abilities, have been developed as therapeutic agents for various neurological diseases. MSC-derived exosomes have been receiving increased attention for their therapeutic capacity and low adverse effects. This review summarizes recent research on the neuroprotective effects of selected MSC-derived exosomal microRNAs (miRNAs) and provides an overview of their application potential in different neurological disorder disease models. It also discusses practical bioengineering approaches for isolating MSC-derived exosomes, manipulating their miRNA cargos, and improving their therapeutic abilities. |
| Publish Date |
2021-07-23 13:30 |
| Citation |
Nasirishargh A, Kumar P, Ramasubramanian L, Clark K, Hao D, Lazar SL, Wang AJ. Exosomal microRNAs from mesenchymal stem/stromal cells: Biology and applications in neuroprotection. World J Stem Cells 2021; 13(7): 776-794 |
| URL |
https://www.wjgnet.com/1948-0210/full/v13/i7/776.htm |
| DOI |
https://dx.doi.org/10.4252/wjsc.v13.i7.776 |
