Publication Name	World Journal of Gastroenterology
Manuscript ID	64194
Country	Italy

Received	2021-02-10 19:51
Peer-Review Started	2021-02-10 19:57
To Make the First Decision
Return for Revision	2021-04-18 22:27
Revised	2021-04-29 18:49
Second Decision	2021-07-13 03:37
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2021-07-13 08:59
Articles in Press	2021-07-13 08:59
Publication Fee Transferred
Edit the Manuscript by Language Editor	2021-07-19 21:24
Typeset the Manuscript	2021-08-06 00:14
Publish the Manuscript Online	2021-08-10 06:48

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved.
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Category	Gastroenterology & Hepatology
Manuscript Type	Review
Article Title	Brain-gut-liver interactions across the spectrum of insulin resistance in metabolic fatty liver disease
Manuscript Source	Invited Manuscript
All Author List	Eleni Rebelos, Patricia Iozzo, Maria Angela Guzzardi, Maurizia Rossana Brunetto and Ferruccio Bonino
ORCID	Author(s) ORCID Number Eleni Rebelos http://orcid.org/0000-0003-3050-8692 Patricia Iozzo http://orcid.org/0000-0001-6443-7074 Maria Angela Guzzardi http://orcid.org/0000-0001-9574-5088 Maurizia Rossana Brunetto http://orcid.org/0000-0001-8364-9152 Ferruccio Bonino http://orcid.org/0000-0001-9942-0328
Funding Agency and Grant Number
Corresponding Author	Ferruccio Bonino, MD, PhD, Professor, Senior Scientist, Institute of Biostructure and Bioimaging , National Research Council , Via Tommaso De Amicis, 95, Napoli 80145, Italy. ferruccio.bonino@unipi.it
Key Words	Metabolic associated fatty liver disease; Non-alcoholic fatty liver disease; Endogenous glucose production; Insulin resistance; Steatohepatitis; Inflammation
Core Tip	From studies using tissue targeted animal models it emerges that neither insulin resistance per se induces hepatic steatosis, nor steatosis induces whole body insulin resistance. However, it is evident that reducing inflammation has several beneficial effects both at the hepatic and whole-body level. In fact inflammation (either hepatic or systemic) acts as major throttle of progressive liver and systemic diseases.
Publish Date	2021-08-10 06:48
Citation	Rebelos E, Iozzo P, Guzzardi MA, Brunetto MR, Bonino F. Brain-gut-liver interactions across the spectrum of insulin resistance in metabolic fatty liver disease. World J Gastroenterol 2021; 27(30): 4999-5018
URL	https://www.wjgnet.com/1007-9327/full/v27/i30/4999.htm
DOI	https://dx.doi.org/10.3748/wjg.v27.i30.4999

Full Article (PDF)	WJG-27-4999.pdf
Full Article (Word)	WJG-27-4999.docx
Manuscript File	64194-Review-FilipodiaCL.docx
Answering Reviewers	64194-Answering reviewers.pdf
Audio Core Tip	64194-Audio core tip.m4a
Conflict-of-Interest Disclosure Form	64194-Conflict-of-interest statement.pdf
Copyright License Agreement	64194-Copyright license agreement.pdf
Supplementary Material	64194-Supplementary material.pdf
Peer-review Report	64194-Peer-review(s).pdf
Scientific Misconduct Check	64194-Scientific misconduct check.pdf
Scientific Editor Work List	64194-Scientific editor work list.pdf
CrossCheck Report	64194-CrossCheck report.pdf