| ISSN |
2307-8960 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Infectious Diseases |
| Manuscript Type |
Case Report |
| Article Title |
Rapid diagnosis of disseminated Mycobacterium mucogenicum infections in formalin-fixed, paraffin-embedded specimen using next-generation sequencing: A case report
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Jing Liu, Zi-Ying Lei, Yi-Hua Pang, Ying-Xiong Huang, Le-Jia Xu, Jian-Yun Zhu, Jia-Xing Zheng, Xiao-Hua Yang, Bing-Liang Lin, Zhi-Liang Gao and Chao Zhuo |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Clinical Research Foundation of the Third Affiliated Hospital of Sun Yat-Sen University |
YHJH201904 |
| National Science and Technology Major Project |
2018ZX10302204 |
|
| Corresponding Author |
Zhi-Liang Gao, BMed, MD, PhD, Chief Physician, Professor, Department of Infectious Diseases, The Third Affiliated Hospital of Sun Yat-sen University, No. 600 Tianhe Road, Guangzhou 510630, Guangdong Province, China. gaozhl@mail.sysu.edu.cn |
| Key Words |
Mycobacterium mucogenicum; Next-generation sequencing; Disseminated infection; Formalin-fixed, paraffin-embedded specimen; Rapid diagnosis; Case report |
| Core Tip |
Mycobacterium mucogenicum (M. mucogenicum) belongs to the group of Nontuberculous mycobacteria, which is associated with a wide spectrum of clinical diseases, including osteomyelitis, respiratory tract, bloodstream, and disseminated infections in both immunocompetent and immunosuppressed individuals. However, time-consuming and low detection rate for identifying this pathogen usually leads to delayed or missed diagnosis. We present a case of disseminated infection with M. mucogenicum diagnosed in formalin-fixed, paraffin-embedded (FFPE) specimen using next-generation sequencing (NGS). NGS is a promising tool for the rapid and accurate diagnosis of rare pathogen, even if using FFPE specimen. |
| Publish Date |
2021-07-07 08:39 |
| Citation |
Liu J, Lei ZY, Pang YH, Huang YX, Xu LJ, Zhu JY, Zheng JX, Yang XH, Lin BL, Gao ZL, Zhuo C. Rapid diagnosis of disseminated Mycobacterium mucogenicum infections in formalin-fixed, paraffin-embedded specimen using next-generation sequencing: A case report. World J Clin Cases 2021; 9(20): 5621-5630 |
| URL |
https://www.wjgnet.com/2307-8960/full/v9/i20/5621.htm |
| DOI |
https://dx.doi.org/10.12998/wjcc.v9.i20.5621 |
