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Articles Published Processes
11/12/2021 11:22:24 AM | Browse: 465 | Download: 896
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Received |
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2021-02-22 14:39 |
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Peer-Review Started |
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2021-02-22 14:44 |
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To Make the First Decision |
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Return for Revision |
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2021-05-08 02:01 |
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Revised |
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2021-05-19 08:40 |
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Second Decision |
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2021-09-22 03:18 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2021-09-23 07:29 |
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Articles in Press |
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2021-09-23 07:29 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2021-11-09 14:33 |
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Publish the Manuscript Online |
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2021-11-12 11:22 |
| ISSN |
1948-5204 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Oncology |
| Manuscript Type |
Case Control Study |
| Article Title |
Genetic variation of TGF-ΒR2 as a protective genotype for the development of colorectal cancer in men
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Noyko Stanilov, Antonia Grigorova, Tsvetelina Velikova and Spaska Angelova Stanilova |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Trakia University, Medical Faculty |
1/2016 |
| Trakia University, Medical Faculty |
2/2019 |
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| Corresponding Author |
Tsvetelina Velikova, MD, PhD, Assistant Professor, Department of Clinical Immunology, University Hospital Lozenetz, Kozyak 1, Sofia 1407, Bulgaria. tsvelikova@medfac.mu-sofia.bg |
| Key Words |
Colorectal carcinoma; Cytokine; TGF-ΒR2 gene; TGF-ΒR2G[-875]A; Single nucleotide polymorphism |
| Core Tip |
Disruptions in transforming growth factor beta (TGF-β)-associated cancer mechanisms are essential in early-stage tumor development, whereas activation of TGF-β-signaling can encourage invasion and metastasis of cancer. Our findings from this case-control study suggested that the highest risk for developing colorectal neoplasia was found for the GG genotype. The increased risk for colorectal cancer (CRC) development was associated with male CRC patients homozygous for the GG genotype. In contrast, male carriers of TGF-ΒR2 -875A allele genotypes of TGF-ΒR2 had a lower risk of CRC development and progression. No other studies for this polymorphism and CRC association from the literature are available to the best of our knowledge. |
| Publish Date |
2021-11-12 11:22 |
| Citation |
Stanilov N, Grigorova A, Velikova T, Stanilova SA. Genetic variation of TGF-ΒR2 as a protective genotype for the development of colorectal cancer in men. World J Gastrointest Oncol 2021; 13(11): 1766-1780 |
| URL |
https://www.wjgnet.com/1948-5204/full/v13/i11/1766.htm |
| DOI |
https://dx.doi.org/10.4251/wjgo.v13.i11.1766 |
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