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Articles Published Processes
8/4/2021 7:56:20 AM | Browse: 353 | Download: 963
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Received |
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2021-02-19 10:25 |
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Peer-Review Started |
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2021-02-19 10:29 |
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To Make the First Decision |
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Return for Revision |
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2021-05-13 00:42 |
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Revised |
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2021-05-17 13:07 |
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Second Decision |
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2021-07-05 12:48 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2021-07-05 14:12 |
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Articles in Press |
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2021-07-05 14:12 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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2021-07-16 07:24 |
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Typeset the Manuscript |
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2021-08-02 03:19 |
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Publish the Manuscript Online |
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2021-08-04 07:56 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Basic Study |
| Article Title |
Impact of Fusobacterium nucleatum in gastrointestinal tract on natural killer cells
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Yeon Ji Kim, Bu Kyung Kim, Seun Ja Park and Jae Hyun Kim |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Research Foundation of Korea (NRF) grant funded by the Korea government (MSIT) |
2017R1C1B5017576 |
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| Corresponding Author |
Jae Hyun Kim, MD, PhD, Assistant Professor, Department of Internal Medicine, Kosin University College of Medicine, 262 Gamcheon-ro, Seo-gu, Busan 49267, South Korea. kjh8517@daum.net |
| Key Words |
Fusobacterium nucleatum; Natural killer cells; Colorectal cancer |
| Core Tip |
Gut microbial dysbiosis contributes to the development and progression of colorectal cancer (CRC). Natural killer (NK) cells are involved in early defense mechanisms to kill infective pathogens and tumor cells by releasing chemokines and cytokines. To better understand any relationship between the gut microbiome and CRC, it was hypothesized here that a high abundance of Fusobacterium nucleatum (F. nucleatum) in the gastrointestinal tract could cause reduced NK cell activity. Accordingly, this association would impact upon the development of CRC in a host. To test this hypothesis, associations between abundance of F. nucleatum in the murine gastrointestinal tract and NK cell activity were evaluated. In this study, we showed that a high abundance of F. nucleatum in the gastrointestinal tract reduced the activity of NK cells and that such outcomes might be associated with a concurrent increase in circulating levels of some pro-inflammatory cytokines, including interleukin-1β and tumor necrosis factor-α in these hosts. These findings suggest that increases in F. nucleatum in the gastrointestinal tract could be a factor in disrupting how the immune system prevents development of CRC. |
| Publish Date |
2021-08-04 07:56 |
| Citation |
Kim YJ, Kim BK, Park SJ, Kim JH. Impact of Fusobacterium nucleatum in the gastrointestinal tract on natural killer cells. World J Gastroenterol 2021; 27(29): 4879-4889 |
| URL |
https://www.wjgnet.com/1007-9327/full/v27/i29/4879.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v27.i29.4879 |
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