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Articles Published Processes
8/10/2021 6:48:42 AM | Browse: 385 | Download: 1115
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Received |
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2021-03-04 05:51 |
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Peer-Review Started |
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2021-03-04 05:54 |
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To Make the First Decision |
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Return for Revision |
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2021-05-05 22:14 |
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Revised |
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2021-05-19 08:46 |
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Second Decision |
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2021-07-05 12:49 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2021-07-05 14:15 |
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Articles in Press |
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2021-07-05 14:15 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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2021-07-26 00:28 |
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Typeset the Manuscript |
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2021-08-06 10:31 |
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Publish the Manuscript Online |
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2021-08-10 06:48 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Neurosciences |
| Manuscript Type |
Basic Study |
| Article Title |
Estrogen augmented visceral pain and colonic neuron modulation in a double-hit model of prenatal and adult stress
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Jing-Hong Chen, Ying Sun, Pei-Jun Ju, Jin-Bao Wei, Qing-Jie Li and John H Winston |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| NIDDK |
5R01DK111819-03 |
| NIDDK |
5R01DK032346-28 |
| National Natural Science Foundation of China |
81571326 |
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| Corresponding Author |
John H Winston, PhD, Professor, Department of Internal Medicine, University of Texas Medical Branch, 8-104 Med Res Bldg, Galveston, TX 77555, United States. jhwinsto@utmb.edu |
| Key Words |
Chronic prenatal stress; Estrogen; Visceral pain; Neuronal sensitization; Excitability; Letrozole |
| Core Tip |
We investigated herein whether estrogen re-enhanced visceral hyperalgesia in chronic prenatal stress plus chronic adult stress models. After using physical ovariectomy or chemical inhibitor Letrozole treatment to reduce estrogen levels, we found that the visceral hyperalgesia, colonic afferent neuronal excitability, nerve growth factor & brain-derived neurotrophic factor, and Estrogen all were increased. The findings indicate that the chronic stress induced visceral hypersensitivity is estrogen dependent and the hypersensitivity is estrogen dependent sensitization of primary afferent colon neurons, which provide key scientific evidence in a preclinical model in support of developing gender-based visceral pain management. |
| Publish Date |
2021-08-10 06:48 |
| Citation |
Chen JH, Sun Y, Ju PJ, Wei JB, Li QJ, Winston JH. Estrogen augmented visceral pain and colonic neuron modulation in a double-hit model of prenatal and adult stress. World J Gastroenterol 2021; 27(30): 5060-5075 |
| URL |
https://www.wjgnet.com/1007-9327/full/v27/i30/5060.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v27.i30.5060 |
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