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Articles Published Processes
1/11/2022 6:48:54 AM | Browse: 604 | Download: 2085
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Received |
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2021-02-18 22:20 |
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Peer-Review Started |
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2021-02-18 22:27 |
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First Decision by Editorial Office Director |
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2021-04-20 18:46 |
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Return for Revision |
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2021-04-20 18:46 |
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Revised |
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2021-04-26 07:55 |
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Publication Fee Transferred |
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Second Decision by Editor |
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2021-12-27 03:37 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2021-12-28 07:55 |
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Articles in Press |
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2021-12-28 07:55 |
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Edit the Manuscript by Language Editor |
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2021-10-12 23:40 |
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Typeset the Manuscript |
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2022-01-05 13:07 |
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Publish the Manuscript Online |
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2022-01-11 06:48 |
| ISSN |
1948-9358 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Endocrinology & Metabolism |
| Manuscript Type |
Basic Study |
| Article Title |
High doses of catecholamines activate glucose transport in human adipocytes independently from adrenoceptor stimulation or vanadium addition
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Christian Carpéné, Nathalie Boulet, Jean-Louis Grolleau and Nathalie Morin |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Christian Carpéné, PhD, Senior Researcher, Institut des Maladies Métaboliques et Cardiovasculaires, INSERM UMR1297, Université Paul Sabatier Toulouse III, CHU Rangueil, Bat L4 BP 84225, Toulouse 31432, France. christian.carpene@inserm.fr |
| Key Words |
Human adipocytes; Amine oxidases; Insulin; Diabetes; Vanadium; Obesity |
| Core Tip |
Since our recent results indicated that the combination of catecholamines plus vanadium strongly stimulates glucose transport in rat adipocytes, we proposed that the study of catecholamine/vanadate salts could lead to the development of novel derivatives exhibiting potent insulin-like properties. When testing this paradigm in human adipocytes, we found in the present study that the extrapolation from animal model to man was not straightforward: adrenaline and noradrenaline stimulated glucose transport in human fat cells, but in a manner that was not dependent on and not enhanced by the presence of vanadate. Consequently, our previously proposed usefulness of the synergism catecholamines/vanadium does not work in human fat cells, and this might hamper the improvement of vanadium-based antidiabetic approaches, limited so far by toxicological issues. |
| Publish Date |
2022-01-11 06:48 |
| Citation |
Carpéné C, Boulet N, Grolleau JL, Morin N. High doses of catecholamines activate glucose transport in human adipocytes independently from adrenoceptor stimulation or vanadium addition. World J Diabetes 2022; 13(1): 37-53 |
| URL |
https://www.wjgnet.com/1948-9358/full/v13/i1/37.htm |
| DOI |
https://dx.doi.org/10.4239/wjd.v13.i1.37 |
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