Publication Name	World Journal of Gastrointestinal Oncology
Manuscript ID	64637
Country	Russia

Received	2021-02-21 14:56
Peer-Review Started	2021-02-21 14:59
To Make the First Decision
Return for Revision	2021-06-16 02:16
Revised	2021-06-19 11:47
Second Decision	2021-08-24 03:23
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2021-08-24 08:13
Articles in Press	2021-08-24 08:13
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2021-09-30 08:31
Publish the Manuscript Online	2021-10-13 12:57

ISSN	1948-5204 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
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Category	Oncology
Manuscript Type	Review
Article Title	Molecular testing for colorectal cancer: Clinical applications
Manuscript Source	Invited Manuscript
All Author List	Evgeny Imyanitov and Ekaterina Kuligina
ORCID	Author(s) ORCID Number Evgeny Imyanitov http://orcid.org/0000-0003-4529-7891 Ekaterina Kuligina http://orcid.org/0000-0002-2396-6540
Funding Agency and Grant Number	Funding Agency Grant Number Ministry of Science and Higher Education of the Russian Federation 075-15-2020-789
Corresponding Author	Evgeny Imyanitov, DSc, Professor, Department of Tumor Biology, N.N. Petrov Institute of Oncology, Pesochny, St.-Petersburg 197758, Russia. evgeny@imyanitov.spb.ru
Key Words	Colorectal cancer; Anti-epidermal growth factor receptor therapy; KRAS; NRAS; BRAF; HER2; Microsatellite instability; MUTYH; Hereditary cancer
Core Tip	Molecular genetic analysis is an integral component of colorectal cancer (CRC) management. Comprehensive KRAS and NRAS testing is mandatory for selection of patients for anti-epidermal growth factor receptor (EGFR) therapy. BRAF V600E mutated cancers are responsive to combination of BRAF and EGFR inhibitors. CRCs with HER2 amplification and overexpression can be controlled by the down-regulation of this receptor. Immune therapy is highly effective in CRCs with exceptionally high tumor mutation burden, e.g., in cancers with microsatellite instability, MUTYH gene inactivation or mutations in the POLE gene. CRC patients with early disease onset, specific tumor features or family history of the disease require germ-line DNA testing.
Publish Date	2021-10-13 12:57
Citation	Imyanitov E, Kuligina E. Molecular testing for colorectal cancer: Clinical applications. World J Gastrointest Oncol 2021; 13(10): 1288-1301
URL	https://www.wjgnet.com/1948-5204/full/v13/i10/1288.htm
DOI	https://dx.doi.org/10.4251/wjgo.v13.i10.1288

Full Article (PDF)	WJGO-13-1288.pdf
Full Article (Word)	WJGO-13-1288.docx
Manuscript File	64637_Auto_Edited-JLW.docx
Answering Reviewers	64637-Answering reviewers.pdf
Audio Core Tip	64637-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	64637-Conflict-of-interest statement.pdf
Copyright License Agreement	64637-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	64637-Grant application form(s).pdf
Peer-review Report	64637-Peer-review(s).pdf
Scientific Misconduct Check	64637-Scientific misconduct check.pdf
Scientific Editor Work List	64637-Scientific editor work list.pdf
CrossCheck Report	64637-CrossCheck report.pdf