Publication Name	World Journal of Gastrointestinal Oncology
Manuscript ID	64684
Country	China

Received	2021-02-22 11:51
Peer-Review Started	2021-02-22 11:51
To Make the First Decision
Return for Revision	2021-06-04 03:34
Revised	2021-06-11 07:45
Second Decision	2021-07-22 03:06
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2021-07-23 05:19
Articles in Press	2021-07-23 05:19
Publication Fee Transferred
Edit the Manuscript by Language Editor	2021-08-17 03:43
Typeset the Manuscript	2021-10-08 02:13
Publish the Manuscript Online	2021-10-13 12:57

ISSN	1948-5204 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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Category	Gastroenterology & Hepatology
Manuscript Type	Minireviews
Article Title	Proliferation cell nuclear antigen clamp associated factor, a potential proto-oncogene with increased expression in malignant gastrointestinal tumors
Manuscript Source	Invited Manuscript
All Author List	Li-Juan Liu, Jian-Ming Liao and Fan Zhu
ORCID	Author(s) ORCID Number Li-Juan Liu http://orcid.org/0000-0002-2549-5463 Jian-Ming Liao http://orcid.org/0000-0002-6196-0510 Fan Zhu http://orcid.org/0000-0001-7031-2956
Funding Agency and Grant Number	Funding Agency Grant Number National Natural Science Foundation of China 81971943 National Natural Science Foundation of China 81772196 Hubei Provincial Natural Science Foundation of China 2020CFB656
Corresponding Author	Fan Zhu, PhD, Professor, State Key Laboratory of Virology and Hubei Province Key Laboratory of Allergy & Immunology, Department of Medical Microbiology, School of Medicine, Wuhan University, No. 185 Donghu Rd, Wuhan 430071, Hubei Province, China. fanzhu@whu.edu.cn
Key Words	Proliferation cell nuclear antigen; Proliferation cell nuclear antigen clamp associated factor; Transcript variant; Gastrointestinal cancers; Signal pathway; Biological therapeutic
Core Tip	In interaction with proliferation cell nuclear antigen (PCNA), PCNA clamp associated factor (PCLAF) plays a crucial role in cell proliferation, DNA repair, and cell cycle regulation. PCLAF shows a causal relationship with gastrointestinal (GI) cancers as PCLAF highly expresses in GI tumors and predicts poor progression. PCLAF also associates with numerous other malignancies and autoimmune diseases. This review discusses the role of PCLAF in GI cancers, as well as the underlying molecular mechanism. Biological therapeutics by targeting PCLAF in cancers are also included.
Publish Date	2021-10-13 12:57
Citation	Liu LJ, Liao JM, Zhu F. Proliferating cell nuclear antigen clamp associated factor, a potential proto-oncogene with increased expression in malignant gastrointestinal tumors. World J Gastrointest Oncol 2021; 13(10): 1425-1439
URL	https://www.wjgnet.com/1948-5204/full/v13/i10/1425.htm
DOI	https://dx.doi.org/10.4251/wjgo.v13.i10.1425

Full Article (PDF)	WJGO-13-1425.pdf
Full Article (Word)	WJGO-13-1425.docx
Manuscript File	64684_Auto_Edited-JPY-Webster J-revised[24335]-Clear.docx
Answering Reviewers	64684-Answering reviewers.pdf
Audio Core Tip	64684-Audio core tip.mp4
Conflict-of-Interest Disclosure Form	64684-Conflict-of-interest statement.pdf
Copyright License Agreement	64684-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	64684-Grant application form(s).pdf
Non-Native Speakers of English Editing Certificate	64684-Language certificate.pdf
Peer-review Report	64684-Peer-review(s).pdf
Scientific Misconduct Check	64684-Scientific misconduct check.pdf
Scientific Editor Work List	64684-Scientific editor work list.pdf
CrossCheck Report	64684-CrossCheck report.pdf