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Articles Published Processes
3/24/2022 9:40:42 AM | Browse: 375 | Download: 635
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Received |
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2021-02-23 13:47 |
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Peer-Review Started |
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2021-02-23 13:54 |
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To Make the First Decision |
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Return for Revision |
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2021-07-29 07:49 |
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Revised |
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2021-09-07 12:04 |
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Second Decision |
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2022-02-18 05:56 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2022-02-20 13:21 |
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Articles in Press |
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2022-02-20 13:21 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2022-03-14 00:23 |
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Publish the Manuscript Online |
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2022-03-24 09:40 |
ISSN |
2218-4333 (online) |
Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
Copyright |
© The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved. |
Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
Website |
http://www.wjgnet.com |
Category |
Oncology |
Manuscript Type |
Review |
Article Title |
Intestinal Wnt in the transition from physiology to oncology
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Manuscript Source |
Invited Manuscript |
All Author List |
Julia Swoboda, Patrick Mittelsdorf, Yuan Chen, Ralf Weiskirchen, Johannes Stallhofer, Silke Schüle and Nikolaus Gassler |
ORCID |
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Funding Agency and Grant Number |
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Corresponding Author |
Nikolaus Gassler, MA, MD, Professor, Section Pathology, Institute of Forensic Medicine, Jena University Hospital, Am Klinikum 1, Jena 07747, Germany. nikolaus.gassler@med.uni-jena.de |
Key Words |
Wnt signaling; Beta-catenin; Intestine; Colorectal cancer; Cell signaling; Intestinal stem cells |
Core Tip |
Wnt signaling pathway is a key regulator of intestinal stem cells. Mutations in this pathway are frequently found in adenomas and carcinomas of the colorectum. Therefore, it represents a potential target for anticancer therapy. This review sums up the physiological role and the regulatory mechanism of Wnt signaling in the human intestine, and moreover, discusses the central role of the Wnt signaling pathway in intestinal carcinogenesis, the morphological features associated with Wnt hyperactivation and clinical relevance of Wnt in the colorectal carcinoma. |
Publish Date |
2022-03-24 09:40 |
Citation |
Swoboda J, Mittelsdorf P, Chen Y, Weiskirchen R, Stallhofer J, Schüle S, Gassler N. Intestinal Wnt in the transition from physiology to oncology. World J Clin Oncol 2022; 13(3): 168-185 |
URL |
https://www.wjgnet.com/2218-4333/full/v13/i3/168.htm |
DOI |
https://dx.doi.org/10.5306/wjco.v13.i3.168 |
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