Publication Name	World Journal of Stem Cells
Manuscript ID	6481
Country	United States

Received	2013-10-20 22:35
Peer-Review Started	2013-10-22 15:13
To Make the First Decision	2013-12-02 11:45
Return for Revision	2013-12-04 21:41
Revised
Second Decision	2014-01-20 09:49
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2014-01-20 10:08
Articles in Press
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2014-04-19 13:08
Publish the Manuscript Online	2014-04-28 14:14

ISSN	1948-0210 (online)
Open Access
Copyright
Article Reprints	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Cell Biology
Manuscript Type	Topic Highlights
Article Title	“Ins” and “Outs” of mesenchymal stem cell osteogenesis in regenerative medicine
Manuscript Source	Invited Manuscript
All Author List	Dean T Yamaguchi
Funding Agency and Grant Number	Funding Agency Grant Number Veterans Administration Merit Review Award 2 I01 BX000170-05
Corresponding Author	Dean T Yamaguchi, MD, PhD, Research Service, Veteran Administration Greater Los Angeles Healthcare System and David Geffen School of Medicine at University of California at Los Angeles, 11301 Wilshire Blvd, Bldg 114, Rm 330, Los Angeles, CA 90073, United States. dean.yamaguchi@va.gov
Key Words	Mesenchymal stem cell; Telomerase reverse transcriptase; Extracellular matrix; Osteogenesis; Regenerative medicine; Tissue engineering; Proliferation; Differentiation
Core Tip	When human telomerase reverse transcriptase (hTERT) transformed human mesenchymal stem cells (hMSCs) are used to prolong replicative potential and osteogenic differentiation, consideration should be given to using lower population doubling hTERT-transformed hMSCs to avoid potential oncogenesis. An inducible hTERT system may also avoid oncogenic transformation. Demonstration of in vivo bone forming capacity of hTERT-transformed cells should be used as standard in determining osteogenic differentiation of such cells rather than in vitro culture mineralization; the CD146 marker may be a suggested surface marker for hTERT-transformed hMSCs that may have the capacity to form bone in vivo. Native ECM from early population doubling hMSCs or hMSCs from a younger source may be best when seeking to extend the proliferative and differentiating potential of hMSCs from either young or older sources.
Publish Date	2014-04-28 14:14
Citation	Yamaguchi DT. “Ins” and “Outs” of mesenchymal stem cell osteogenesis in regenerative medicine. World J Stem Cells 2014; 6(2): 94-110
URL	http://www.wjgnet.com/1948-0210/full/v6/i2/94.htm
DOI	http://dx.doi.org/10.4252/wjsc.v6.i2.94

Full Article (PDF)	WJSC-6-94.pdf
Full Article (Word)	WJSC-6-94.doc
Manuscript File	6481-Review.docx
Answering Reviewers	6481-Answering reviewers.pdf
Copyright License Agreement	6481-Copyright assignment.pdf
Institutional Review Board Approval Form or Document	Ethics_Committee_20131020021620.docx
Peer-review Report	6481-Peer review(s).pdf
Scientific Editor Work List	6481-Scientific editor work list.doc