| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Autobiography |
| Article Title |
Safety and efficacy of Hansenula-derived PEGylated-interferon alpha-2a and ribavirin combination in chronic hepatitis C Egyptian children
|
| Manuscript Source |
Invited Manuscript |
| All Author List |
Suzan El Naghi, Tawhida Y Abdel-Ghaffar, Hanaa El-Karaksy, Elham F Abdel-Aty, Mona S El-Raziky, Aleef A Allam, Heba Helmy, Hanaa A El-Araby, Behairy E Behairy, Mohamed A El-Guindi, Hatem El-Sebaie, Aisha Y Abdel-Ghaffar, Nermin A Ehsan, Ahmed M El-Hennawy and Mostafa M Sira |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Yassin Abdel-Ghaffar Charity Center for Liver Disease and Research, Cairo, Egypt |
|
| National Liver Institute, Menofiya University, Egypt |
|
| Cairo University Pediatric Hospital, Cairo, Egypt |
|
|
| Corresponding Author |
Mostafa M Sira, MD, Department of Pediatric Hepatology, National Liver Institute, Menofiya University, Gamal Abd El-Nasir, Shebin El-koom, 32511 Menofiya, Egypt. msira@liver-eg.org |
| Key Words |
Children; Chronic hepatitis C; Hansenula polymorpha; PEGylated interferon; Response rate; Ribavirin; Treatment |
| Core Tip |
Egypt has the highest prevalence of hepatitis C virus (HCV) infection in the world (15%-25%) and the main (90%) genotype is type 4. Prevalence in Egyptian children was found to be 3% in upper Egypt and 9% in lower Egypt. PEG-IFN-alpha-2a or -2b and ribavirin have been used in small numbers of HCV-infected children, whose SVRs are higher in genotypes 2/3 than in genotypes 1/4. A novel 20-kDa PEG-IFN-alpha-2a (Reiferon Retard) derived from the Hansenula polymorpha expression system has been used in adults with chronic HCV, achieving an SVR ranging from 56% to 60.7%, while no studies have been reported in children before. |
| Publish Date |
2014-04-29 09:53 |
| Citation |
El Naghi S, Abdel-Ghaffar TY, El-Karaksy H, Abdel-Aty EF, El-Raziky MS, Allam AA, Helmy H, El-Araby HA, Behairy BE, El-Guindi MA et al. Safety and efficacy of Hansenula-derived PEGylated-interferon alpha-2a and ribavirin combination in chronic hepatitis C Egyptian children. World J Gastroenterol 2014; 20(16): 4681-4691 |
| URL |
http://www.wjgnet.com/1007-9327/full/v20/i16/4681.htm |
| DOI |
http://dx.doi.org/10.3748/wjg.v20.i16.4681 |
