Publication Name	World Journal of Stem Cells
Manuscript ID	64854
Country	Ukraine

Received	2021-02-24 13:06
Peer-Review Started	2021-02-24 13:09
To Make the First Decision
Return for Revision	2021-04-20 02:17
Revised	2021-04-28 09:21
Second Decision	2021-07-29 02:54
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2021-07-29 06:39
Articles in Press	2021-07-29 06:39
Publication Fee Transferred
Edit the Manuscript by Language Editor	2021-08-04 23:44
Typeset the Manuscript	2021-08-17 09:45
Publish the Manuscript Online	2021-08-20 05:46

ISSN	1948-0210 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Copyright	© The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved.
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Category	Neurosciences
Manuscript Type	Minireviews
Article Title	Mesenchymal stem cells as a potential therapeutic tool to cure cognitive impairment caused by neuroinflammation
Manuscript Source	Invited Manuscript
All Author List	Maryna Skok
ORCID	Author(s) ORCID Number Maryna Skok http://orcid.org/0000-0002-5816-605X
Funding Agency and Grant Number
Corresponding Author	Maryna Skok, DSc, Academic Fellow, Professor, Senior Researcher, Department of Molecular Immunology, Palladin Institute of Biochemistry NAS of Ukraine, 9 Leontovicha str., Kyiv 01054, Ukraine. skok@biochem.kiev.ua
Key Words	Mesenchymal stem cells; Neuroinflammation; Cognition; α7 Nicotinic acetylcholine receptor; Extracellular vesicles; Alzheimer disease
Core Tip	Mesenchymal stem cells (MSCs) have a significant therapeutic potential in treating neuroinflammation-related cognitive disfunctions including age-related neurodegenerative diseases. The review summarizes recent data concerning optimization of MSCs use for therapeutic purposes with the emphasis on the achievements of the last two years. Specific attention is paid to extracellular vesicles secreted by MSCs and to the role of α7 nicotinic acetylcholine receptors. The main conclusion is that therapeutic application of MSCs should include measures to facilitate their homing to the brain, support the survival in the brain microenvironment and stimulate the production of neurotrophic and anti-inflammatory factors.
Publish Date	2021-08-20 05:46
Citation	Skok M. Mesenchymal stem cells as a potential therapeutic tool to cure cognitive impairment caused by neuroinflammation. World J Stem Cells 2021; 13(8): 1072-1083
URL	https://www.wjgnet.com/1948-0210/full/v13/i8/1072.htm
DOI	https://dx.doi.org/10.4252/wjsc.v13.i8.1072

Full Article (PDF)	WJSC-13-1072.pdf
Full Article (Word)	WJSC-13-1072.docx
Manuscript File	64854-Review-FilipodiaCL.docx
Answering Reviewers	64854-Answering reviewers.pdf
Audio Core Tip	64854-Audio core tip.m4a
Conflict-of-Interest Disclosure Form	64854-Conflict-of-interest statement.pdf
Copyright License Agreement	64854-Copyright license agreement.pdf
Non-Native Speakers of English Editing Certificate	64854-Language certificate.pdf
Peer-review Report	64854-Peer-review(s).pdf
Scientific Misconduct Check	64854-Bing-Fan JR-2.png
Scientific Misconduct Check	64854-Scientific misconduct check.pdf
Scientific Editor Work List	64854-Scientific editor work list.pdf
CrossCheck Report	64854-CrossCheck report.pdf
CrossCheck Report	64854-CrossCheck.png