Publication Name	World Journal of Psychiatry
Manuscript ID	64940
Country	Canada

Received	2021-02-25 15:14
Peer-Review Started	2021-02-25 15:14
To Make the First Decision
Return for Revision	2021-04-20 23:52
Revised	2021-04-22 13:07
Second Decision	2021-06-22 14:08
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2021-06-22 14:25
Articles in Press	2021-06-22 14:25
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2021-07-14 06:47
Publish the Manuscript Online	2021-07-15 10:19

ISSN	2220-3206 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
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Category	Psychiatry
Manuscript Type	Minireviews
Article Title	History of the dopamine hypothesis of antipsychotic action
Manuscript Source	Invited Manuscript
All Author List	Mary V Seeman
ORCID	Author(s) ORCID Number Mary V Seeman http://orcid.org/0000-0001-6797-3382
Funding Agency and Grant Number
Corresponding Author	Mary V Seeman, DSc, MDCM, OC, Professor Emerita, Department of Psychiatry, University of Toronto, 260 Heath Street West, Suite #605, Toronto M5P 3L6, Ontario, Canada. mary.seeman@utoronto.ca
Key Words	Chlorpromazine; Haloperidol; G-Protein coupled receptors; Binding assays; Receptor imaging; High affinity states
Core Tip	This history starts with the synthesis of chlorpromazine in 1950 and traces the steps taken to discover how this drug, and related drugs, work to reduce, sometimes to reverse, the delusions and hallucinations associated with psychosis. The task to understand how these drugs work in the brain continues, as many unknowns remain.
Publish Date	2021-07-15 10:19
Citation	Seeman MV. History of the dopamine hypothesis of antipsychotic action. World J Psychiatr 2021; 11(7): 355-364
URL	https://www.wjgnet.com/2220-3206/full/v11/i7/355.htm
DOI	https://dx.doi.org/10.5498/wjp.v11.i7.355

Full Article (PDF)	WJP-11-355.pdf
Full Article (Word)	WJP-11-355.docx
Manuscript File	64940_Auto_Edited-ZMG.docx
Answering Reviewers	64940-Answering reviewers.pdf
Audio Core Tip	64940-Audio core tip.m4a
Conflict-of-Interest Disclosure Form	64940-Conflict-of-interest statement.pdf
Copyright License Agreement	64940-Copyright license agreement.pdf
Peer-review Report	64940-Peer-review(s).pdf
Scientific Misconduct Check	64940-Bing-Ma YJ-1.jpg
Scientific Misconduct Check	64940-Bing-Fan JR-2.png
Scientific Misconduct Check	64940-Scientific misconduct check.pdf
Scientific Editor Work List	64940-Scientific editor work list.pdf
CrossCheck Report	64940-CrossCheck report.pdf
CrossCheck Report	64940-CrossCheck.png