Publication Name	World Journal of Stem Cells
Manuscript ID	65011
Country	Italy

Received	2021-03-13 21:26
Peer-Review Started	2021-03-13 21:29
To Make the First Decision
Return for Revision	2021-04-06 00:57
Revised	2021-04-26 12:39
Second Decision	2021-06-22 09:08
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2021-06-22 10:03
Articles in Press	2021-06-22 10:03
Publication Fee Transferred
Edit the Manuscript by Language Editor	2021-06-27 00:15
Typeset the Manuscript	2021-07-21 14:05
Publish the Manuscript Online	2021-07-23 13:30

ISSN	1948-0210 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Copyright	© The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved.
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Website	http://www.wjgnet.com

Category	Oncology
Manuscript Type	Opinion Review
Article Title	Epigenetic modulators for brain cancer stem cells: Implications for anticancer treatment
Manuscript Source	Invited Manuscript
All Author List	Luana Abballe and Evelina Miele
ORCID	Author(s) ORCID Number Luana Abballe http://orcid.org/0000-0003-4446-2293 Evelina Miele http://orcid.org/0000-0002-4747-1032
Funding Agency and Grant Number	Funding Agency Grant Number Italian Ministry of Health, Ricerca Finalizzata GR-2018-12367328
Corresponding Author	Evelina Miele, MD, PhD, Medical Assistant, Postdoc, Research Scientist, Department of Pediatric Hematology/Oncology and Cellular and Gene Therapy, Bambino Gesù Children's Hospital, IRCCS, Piazza di Sant'Onofrio, 4, Rome 00165, Italy. evelina.miele@opbg.net
Key Words	Cancer stem cells; Epigenetics; Brain tumors; Epigenetic drugs; Histone deacetylase inhibitors; DNA methyltransferase inhibitors
Core Tip	Cancer stem cells (CSCs) are characterized by an altered epigenome that contributes to treatment failure and tumor relapse. Physicians are looking for new therapeutic approaches to specifically targeted CSCs in cancers. In this review, we summarize literature data about epigenetic marks in brain CSCs and shed light on new epigenetic therapies.
Publish Date	2021-07-23 13:30
Citation	Abballe L, Miele E. Epigenetic modulators for brain cancer stem cells: Implications for anticancer treatment. World J Stem Cells 2021; 13(7): 670-684
URL	https://www.wjgnet.com/1948-0210/full/v13/i7/670.htm
DOI	https://dx.doi.org/10.4252/wjsc.v13.i7.670

Full Article (PDF)	WJSC-13-670.pdf
Full Article (Word)	WJSC-13-670.docx
Manuscript File	65011_Review-FilipodiaCL.docx
Answering Reviewers	65011-Answering reviewers.pdf
Audio Core Tip	65011-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	65011-Conflict-of-interest statement.pdf
Copyright License Agreement	65011-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	65011-Grant application form(s).pdf
Non-Native Speakers of English Editing Certificate	65011-Language certificate.pdf
Peer-review Report	65011-Peer-review(s).pdf
Scientific Misconduct Check	65011-Bing-Wang JL-1.jpg
Scientific Misconduct Check	65011-CrossCheck.png
Scientific Misconduct Check	65011-Bing-Gong ZM-2.png
Scientific Misconduct Check	65011-Scientific misconduct check.pdf
Scientific Editor Work List	65011-Scientific editor work list.pdf
CrossCheck Report	65011-CrossCheck report.pdf