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Articles Published Processes
2/9/2022 6:44:54 AM | Browse: 418 | Download: 1005
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Received |
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2021-02-26 13:38 |
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Peer-Review Started |
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2021-02-26 13:45 |
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To Make the First Decision |
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Return for Revision |
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2021-04-20 18:38 |
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Revised |
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2021-04-27 10:23 |
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Second Decision |
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2022-01-19 03:57 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2022-01-20 05:34 |
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Articles in Press |
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2022-01-20 05:34 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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2022-01-08 21:43 |
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Typeset the Manuscript |
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2022-01-27 08:02 |
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Publish the Manuscript Online |
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2022-02-09 06:44 |
| ISSN |
1948-9358 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Endocrinology & Metabolism |
| Manuscript Type |
Minireviews |
| Article Title |
Metabolically healthy obesity: Is it really healthy for type 2 diabetes mellitus?
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Qi Wu, Ming-Feng Xia and Xin Gao |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Shanghai Municipal Science and Technology Major Project |
2017SHZDZX01 |
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| Corresponding Author |
Ming-Feng Xia, MD, Associate Professor, Attending Doctor, Department of Endocrinology and Metabolism, Zhongshan Hospital, Fudan University, No. 180 Fenglin Road, Shanghai 200032, China. dr_xiamingfeng@163.com |
| Key Words |
Metabolically healthy obesity; Type 2 diabetes; Non-alcoholic fatty liver diseases; Insulin resistance; Low-grade inflammatory status; Beta-cell dysfunction |
| Core Tip |
Metabolically healthy obese individuals have already developed impaired insulin sensitivity with dysfunction of insulin action on subcutaneous tissue, as well as a tendency for beta-cell dysfunction and a chronic low-grade inflammatory status compared with metabolically healthy normal-weight individuals. Thus, it is an unfavorable phenotype for type 2 diabetes, with metabolic changes preceding the incidence of diabetes. Liver fat content might be an important contributor to the development of diabetes in metabolically healthy obesity among all risk factors. More attention should be paid to the weight management and metabolic status of these individuals. |
| Publish Date |
2022-02-09 06:44 |
| Citation |
Wu Q, Xia MF, Gao X. Metabolically healthy obesity: Is it really healthy for type 2 diabetes mellitus? World J Diabetes 2022; 13(2): 70-84 |
| URL |
https://www.wjgnet.com/1948-9358/full/v13/i2/70.htm |
| DOI |
https://dx.doi.org/10.4239/wjd.v13.i2.70 |
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