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Articles Published Processes
9/7/2021 8:15:21 AM | Browse: 698 | Download: 1124
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Received |
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2021-02-26 16:45 |
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Peer-Review Started |
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2021-02-26 16:55 |
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To Make the First Decision |
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Return for Revision |
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2021-04-20 18:33 |
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Revised |
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2021-04-24 06:54 |
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Second Decision |
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2021-08-13 02:57 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2021-08-13 06:28 |
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Articles in Press |
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2021-08-13 06:28 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2021-09-01 09:16 |
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Publish the Manuscript Online |
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2021-09-07 08:15 |
| ISSN |
1948-9358 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Endocrinology & Metabolism |
| Manuscript Type |
Review |
| Article Title |
Holistic perspective of the role of gut microbes in diabetes mellitus and its management
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Kannayiram Alagiakrishnan and Tyler Halverson |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Kannayiram Alagiakrishnan, FRCPC, MD, Full Professor, Department of Medicine, University of Alberta, B139-152 University Hospital Clinical Sciences Building, Edmonton T6G 2G3, Alberta, Canada. kalagiakri@aol.com |
| Key Words |
Probiotics; Prebiotics; Synbiotics; Diabetes mellitus; Microbial dysbiosis; Antidiabetic drugs |
| Core Tip |
The emerging role of the gut microbiome on diabetes development, progression as well as prevention has been discussed in this manuscript. The significance of gut dysbiosis in the aetiopathogenesis of diabetes mellitus and its complications has been reviewed. A bidirectional relationship exists between the antidiabetic drugs and the gut microbiome. Faecal transplantation, and bariatric surgery, typically used to treat morbid obesity, have also been shown to improve commensal gut microbiota changes. Diabetic outcomes and management can improve with better understanding of the drug-gut microbiome interactions. There is emerging evidence pointing out that gut biotics can be an add-on therapy with the antidiabetic management. To our knowledge, there is no evidence about the role of gut microbes of diabetic patients who had pancreatic cell transplantation, as well as the role of gut biotics influencing the management in this group. |
| Publish Date |
2021-09-07 08:15 |
| Citation |
Alagiakrishnan K, Halverson T. Holistic perspective of the role of gut microbes in diabetes mellitus and its management. World J Diabetes 2021; 12(9): 1463-1478 |
| URL |
https://www.wjgnet.com/1948-9358/full/v12/i9/1463.htm |
| DOI |
https://dx.doi.org/10.4239/wjd.v12.i9.1463 |
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