Publication Name	World Journal of Clinical Oncology
Manuscript ID	65070
Country	Lebanon

Received	2021-02-27 11:51
Peer-Review Started	2021-02-27 12:01
To Make the First Decision
Return for Revision	2021-03-31 04:49
Revised	2021-04-11 16:18
Second Decision	2021-06-18 08:13
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2021-06-18 11:41
Articles in Press	2021-06-18 11:41
Publication Fee Transferred
Edit the Manuscript by Language Editor	2021-06-25 20:58
Typeset the Manuscript	2021-07-20 04:43
Publish the Manuscript Online	2021-07-21 09:30

ISSN	2218-4333 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Copyright	© The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved.
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Website	http://www.wjgnet.com

Category	Oncology
Manuscript Type	Review
Article Title	Therapeutic potential of thymoquinone in combination therapy against cancer and cancer stem cells
Manuscript Source	Invited Manuscript
All Author List	Zaynab Fatfat, Maamoun Fatfat and Hala Gali-Muhtasib
ORCID	Author(s) ORCID Number Zaynab Fatfat http://orcid.org/0000-0003-1254-0648 Maamoun Fatfat http://orcid.org/0000-0001-9642-6708 Hala Gali-Muhtasib http://orcid.org/0000-0001-6840-3015
Funding Agency and Grant Number
Corresponding Author	Hala Gali-Muhtasib, PhD, Professor, Department of Biology, American University of Beirut, Bliss Street, Beirut 1107 2020, Lebanon. amro@aub.edu.lb
Key Words	Thymoquinone; Combination therapy; Cancer cells; Cancer stem cells; Conventional cancer therapy; Natural products
Core Tip	There has been great interest in integrating thymoquinone (TQ) in combination therapy particularly to target cancer stem cells which are known to be responsible for resistance to treatment and cancer recurrence. The combination of TQ with standard chemotherapeutics and other natural products has exhibited promising anticancer responses. TQ was also shown to sensitize cancer cells to radiotherapy and help in overcoming major limitations that restrict the potency of chemotherapy which are chemoresistance and treatment associated toxic effects.
Publish Date	2021-07-21 09:30
Citation	Fatfat Z, Fatfat M, Gali-Muhtasib H. Therapeutic potential of Thymoquinone in combination therapy against cancer and cancer stem cells. World J Clin Oncol 2021; 12(7): 522-543
URL	https://www.wjgnet.com/2218-4333/full/v12/i7/522.htm
DOI	https://dx.doi.org/10.5306/wjco.v12.i7.522

Full Article (PDF)	WJCO-12-522.pdf
Full Article (Word)	WJCO-12-522.docx
Manuscript File	65070-Review-Filipodia-CL.docx
Answering Reviewers	65070-Answering reviewers.pdf
Audio Core Tip	65070-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	65070-Conflict-of-interest statement.pdf
Copyright License Agreement	65070-Copyright license agreement.pdf
Non-Native Speakers of English Editing Certificate	65070-Language certificate.pdf
Peer-review Report	65070-Peer-review(s).pdf
Scientific Misconduct Check	65070-Scientific misconduct check.pdf
Scientific Editor Work List	65070-Scientific editor work list.pdf
CrossCheck Report	65070-CrossCheck report.pdf