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Articles Published Processes
8/20/2021 5:46:25 AM | Browse: 508 | Download: 1254
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Received |
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2021-02-28 00:31 |
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Peer-Review Started |
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2021-02-28 00:31 |
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To Make the First Decision |
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Return for Revision |
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2021-04-19 20:11 |
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Revised |
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2021-05-03 06:54 |
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Second Decision |
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2021-07-14 03:33 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2021-07-14 08:09 |
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Articles in Press |
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2021-07-14 08:09 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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2021-07-23 06:09 |
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Typeset the Manuscript |
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2021-08-19 01:58 |
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Publish the Manuscript Online |
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2021-08-20 05:46 |
| ISSN |
1948-0210 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Research & Experimental Medicine |
| Manuscript Type |
Minireviews |
| Article Title |
Methods to produce induced pluripotent stem cell-derived mesenchymal stem cells: Mesenchymal stem cells from induced pluripotent stem cells
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Victoria Dupuis and Elisa Oltra |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Elisa Oltra, PhD, Full Professor, Department of Pathology, Universidad Católica de Valencia San Vicente Mártir, C/Quevedo 2, Valencia 46001, Spain. elisa.oltra@ucv.es |
| Key Words |
Mesenchymal stem cells; Induced pluripotent stem cell; Mesenchymal stem cells derived from induced pluripotent stem cells; Differentiation methods; Culture components; Mesenchymal stem cell markers |
| Core Tip |
Heterogeneity of mesenchymal stem cells (MSCs) quality might have hampered the robust success of stem-cell clinical trials (CTs). The production of MSCs from a single homogeneous source (i.e., induced pluripotent stem cells, iPSCs) could elevate stem-cell therapeutics standardization to unprecedented levels. However, a unique optimized procedure for large-scale production of MSCs, of homogenous quality, from iPSCs (iMSCs) is missing. Main methods, culture components, and common MSC markers to produce iMSCs are provided here as reference resources for the establishment of harmonized GMPs (Good Manufacturing Procedures) towards obtaining clinical grade iMSCs with improved CT performance. |
| Publish Date |
2021-08-20 05:46 |
| Citation |
Dupuis V, Oltra E. Methods to produce induced pluripotent stem cell-derived mesenchymal stem cells: Mesenchymal stem cells from induced pluripotent stem cells. World J Stem Cells 2021; 13(8): 1094-1111 |
| URL |
https://www.wjgnet.com/1948-0210/full/v13/i8/1094.htm |
| DOI |
https://dx.doi.org/10.4252/wjsc.v13.i8.1094 |
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