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Articles Published Processes
8/10/2021 6:48:42 AM | Browse: 474 | Download: 980
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Received |
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2021-03-03 00:18 |
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Peer-Review Started |
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2021-03-03 00:21 |
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To Make the First Decision |
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Return for Revision |
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2021-04-17 14:06 |
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Revised |
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2021-05-01 21:31 |
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Second Decision |
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2021-07-12 03:37 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2021-07-12 09:45 |
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Articles in Press |
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2021-07-12 09:45 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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2021-07-20 03:03 |
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Typeset the Manuscript |
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2021-08-06 10:33 |
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Publish the Manuscript Online |
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2021-08-10 06:48 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Infectious Diseases |
| Manuscript Type |
Minireviews |
| Article Title |
Gastrointestinal mucosal immunity and COVID-19
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Tsvetelina Velikova, Violeta Snegarova, Alexander Kukov, Hristiana Batselova, Antoaneta Mihova and Radislav Nakov |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Tsvetelina Velikova, MD, PhD, Assistant Professor, Department of Clinical Immunology, University Hospital Lozenetz, Medical Faculty, Sofia University, St. Kliment Ohridski, Kozyak 1 str, Sofia 1407, Bulgaria. tsvelikova@medfac.mu-sofia.bg |
| Key Words |
Mucosa; Gut mucosa; Mucosa-associated lymphoid tissue; SARS-CoV-2; COVID-19; Secretory immunoglobulin A; Gut microbiota |
| Core Tip |
Gastrointestinal tract is also a substantial route for infection with severe acute respiratory syndrome coronavirus 2. Given the complex interactions between the virus and the mucosal immune system after the exposure, additional research is needed to elucidate the immune mechanisms and processes in the gut mucosa. The hallmark of all immune responses is the recruitment of various immune cells, such as neutrophils, dendritic cells, macrophages, and T cells in the gut mucosa. However, the mucosal inflammatory response could change intercellular space between enterocytes, leading to an increase in intestinal permeability, which allows different bacterial antigens and toxins to enter the bloodstream, further complicated the disease state of coronavirus disease 2019 patients. |
| Publish Date |
2021-08-10 06:48 |
| Citation |
Velikova T, Snegarova V, Kukov A, Batselova H, Mihova A, Nakov R. Gastrointestinal mucosal immunity and COVID-19 . World J Gastroenterol 2021; 27(30): 5047-5059 |
| URL |
https://www.wjgnet.com/1007-9327/full/v27/i30/5047.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v27.i30.5047 |
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