| ISSN |
1948-0210 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Orthopedics |
| Manuscript Type |
Review |
| Article Title |
Effects of immune cells on mesenchymal stem cells during fracture healing
|
| Manuscript Source |
Invited Manuscript |
| All Author List |
Sabrina Ehnert, Borna Relja, Katharina Schmidt-Bleek, Verena Fischer, Anita Ignatius, Caren Linnemann, Helen Rinderknecht, Markus Huber-Lang, Miriam Kalbitz, Tina Histing and Andreas K Nussler |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| German Research Foundation (DFG) focusing on “Interplay between mononuclear and osteogenic cells during fracture healing in type 2 diabetics“ |
EH 471/2 |
| German Research Foundation within the context of the Collaborative Research Center (CRC) 1149 “Danger Response, Disturbance Factors and Regenerative Potential after Acute Trauma” |
251293561, C01 |
| DFG in context of the CRC 1149 |
251293561 |
| DFG in context of the CRC 1149 |
251293561 Z02 |
| DFG in the context of the CRC 1149 |
251293561, C07 |
|
| Corresponding Author |
Andreas K Nussler, PhD, Academic Research, Director, Director, Pharmacist, Professor, Senior Scientist, Siegfried Weller Research Institute at the BG Trauma Center Tübingen, Department of Trauma and Reconstructive Surgery, University of Tübingen, Schnarrenbergstr. 95, Tübingen 72076, Germany. andreas.nuessler@med.uni-tuebingen.de |
| Key Words |
Trauma; Bones; Immune response; Mesenchymal stem cells; Fracture healing |
| Core Tip |
There is substantial evidence that immune cells influence mesenchymal stem cells (MSCs) after trauma. Bone is considered as an osteoimmune system based on cooperatively acting bone and immune cells, cohabitating within the bone marrow. The subdivisions are highly interdependent, sharing progenitors, mediators, and signaling pathways. During fracture healing many different cell types categorized to the innate and adaptive immune system interact. MSCs with their manifold immunomodulatory and regenerative properties serve as progenitors for fibroblasts, chondrocytes and osteoblasts. The alterations in the immune response usually become apparent early in the healing process of a fracture. This opens new avenues for early interventions. |
| Publish Date |
2021-11-25 08:31 |
| Citation |
Ehnert S, Relja B, Schmidt-Bleek K, Fischer V, Ignatius A, Linnemann C, Rinderknecht H, Huber-Lang M, Kalbitz M, Histing T, Nussler AK. Effects of immune cells on mesenchymal stem cells during fracture healing. World J Stem Cells 2021; 13(11): 1667-1695 |
| URL |
https://www.wjgnet.com/1948-0210/full/v13/i11/1667.htm |
| DOI |
https://dx.doi.org/10.4252/wjsc.v13.i11.1667 |
