Publication Name	World Journal of Gastroenterology
Manuscript ID	6518
Country	Brazil

Received	2013-10-22 12:01
Peer-Review Started	2013-10-22 18:59
To Make the First Decision	2013-12-04 08:34
Return for Revision	2013-12-04 17:07
Revised	2013-12-18 22:06
Second Decision	2014-01-20 17:02
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2014-01-20 18:06
Articles in Press
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2014-03-25 11:54
Publish the Manuscript Online	2014-04-17 13:27

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
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Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Autobiography
Article Title	Hepcidin expression in colon during trinitrobenzene sulfonic acid-induced colitis in rats
Manuscript Source	Invited Manuscript
All Author List	Érica Martins Ferreira Gotardo, Gilberto de Almeida Ribeiro, Thayane Rodrigues Leite Clemente, Camila Henrique Moscato, Renata Bortolin Guerra Tomé, Thalita Rocha, José Pedrazzoli Jr, Marcelo Lima Ribeiro and Alessandra Gambero
Funding Agency and Grant Number	Funding Agency Grant Number Fundação de Amparo à Pesquisa do Estado de São Paulo FAPESP 2010/02991-6
Corresponding Author	Alessandra Gambero, PhD, Clinical Pharmacology and Gastroenterology Unit, São Francisco University Medical School, Av. São Francisco de Assis 218, Bragança Paulista, SP 12916-900, Brazil. alessandra.gambero@usf.edu.br
Key Words	Hepcidin-25; Interleukin-6; Iron; Stat-3; Anemia; Toll-like receptor 4
Core Tip	Hepcidin is an endogenous peptide with weak antimicrobial properties that regulates changes in iron metabolism during inflammation. However, infection-associated cytokines, pathogen-derived molecules or whole pathogens can induce hepcidin synthesis as part of the host response to infection. This is the first study to describe that colitis induces hepcidin expression in colons associated with the Interleukin-6/Stat-3 signaling pathways and local iron sequestration. This finding suggests a host response to infection because reducing the iron available to pathogens is an important antimicrobial mechanism. However, we could not exclude the possibility that hepcidin expression contributes to increased local inflammation by stimulating pro-inflammatory macrophages.
Publish Date	2014-04-17 13:27
Citation	Gotardo EMF, Ribeiro GA, Clemente TRL, Moscato CH, Tomé RBG, Rocha T, Pedrazzoli Jr J, Ribeiro ML, Gambero A. Hepcidin expression in colon during trinitrobenzene sulfonic acid-induced colitis in rats. World J Gastroenterol 2014; 20(15): 4345-4352
URL	http://www.wjgnet.com/1007-9327/full/v20/i15/4345.htm
DOI	http://dx.doi.org/10.3748/wjg.v20.i15.4345

Full Article (PDF)	WJG-20-4345.pdf
Full Article (Word)	WJG-20-4345.doc
Manuscript File	6518-Review.docx
Answering Reviewers	6518-Answering reviewers.pdf
Biostatistics Review Certificate	Biostatistician_Review_Report_20131022021406.doc
Copyright License Agreement	6518-Copyright assignment.pdf
Institutional Review Board Approval Form or Document	Ethics_Committee_20131022021144.pdf
Non-Native Speakers of English Editing Certificate	6518-Language certificate.pdf
Peer-review Report	6518-Peer review(s).pdf
Scientific Editor Work List	6518-Scientific editor work list.doc