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8/29/2014 11:31:00 AM | Browse: 418 | Download: 290
Publication Name World Journal of Gastroenterology
Manuscript ID 6518
Country/Territory Brazil
Received
2013-10-22 12:01
Peer-Review Started
2013-10-22 18:59
To Make the First Decision
2013-12-04 08:34
Return for Revision
2013-12-04 17:07
Revised
2013-12-18 22:06
Second Decision
2014-01-20 17:02
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2014-01-20 18:06
Articles in Press
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2014-03-25 11:54
Publish the Manuscript Online
2014-04-17 13:27
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Gastroenterology and Hepatology
Manuscript Type Autobiography
Article Title Hepcidin expression in colon during trinitrobenzene sulfonic acid-induced colitis in rats
Manuscript Source Invited Manuscript
All Author List Érica Martins Ferreira Gotardo, Gilberto de Almeida Ribeiro, Thayane Rodrigues Leite Clemente, Camila Henrique Moscato, Renata Bortolin Guerra Tomé, Thalita Rocha, José Pedrazzoli Jr, Marcelo Lima Ribeiro and Alessandra Gambero
Funding Agency and Grant Number
Funding Agency Grant Number
Fundação de Amparo à Pesquisa do Estado de São Paulo FAPESP 2010/02991-6
Corresponding author Alessandra Gambero, PhD, Clinical Pharmacology and Gastroenterology Unit, São Francisco University Medical School, Av. São Francisco de Assis 218, Bragança Paulista, SP 12916-900, Brazil. alessandra.gambero@usf.edu.br
Keywords Hepcidin-25; Interleukin-6; Iron; Stat-3; Anemia; Toll-like receptor 4
Core Tip Hepcidin is an endogenous peptide with weak antimicrobial properties that regulates changes in iron metabolism during inflammation. However, infection-associated cytokines, pathogen-derived molecules or whole pathogens can induce hepcidin synthesis as part of the host response to infection. This is the first study to describe that colitis induces hepcidin expression in colons associated with the Interleukin-6/Stat-3 signaling pathways and local iron sequestration. This finding suggests a host response to infection because reducing the iron available to pathogens is an important antimicrobial mechanism. However, we could not exclude the possibility that hepcidin expression contributes to increased local inflammation by stimulating pro-inflammatory macrophages.
Publish Date 2014-04-17 13:27
Citation Gotardo EMF, Ribeiro GA, Clemente TRL, Moscato CH, Tomé RBG, Rocha T, Pedrazzoli Jr J, Ribeiro ML, Gambero A. Hepcidin expression in colon during trinitrobenzene sulfonic acid-induced colitis in rats. World J Gastroenterol 2014; 20(15): 4345-4352
Url http://www.wjgnet.com/1007-9327/full/v20/i15/4345.htm
DOI http://dx.doi.org/10.3748/wjg.v20.i15.4345
Full Article (PDF) WJG-20-4345.pdf
Full Article (Word) WJG-20-4345.doc
Manuscript File 6518-Review.docx
Answering Reviewers 6518-Answering reviewers.pdf
Biostatistics Review Certificate Biostatistician_Review_Report_20131022021406.doc
Copyright License Agreement 6518-Copyright assignment.pdf
Institutional Review Board Approval Form or Document Ethics_Committee_20131022021144.pdf
Non-Native Speakers of English Editing Certificate 6518-Language certificate.pdf
Peer-review Report 6518-Peer review(s).pdf
Scientific Editor Work List 6518-Scientific editor work list.doc