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Articles Published Processes
9/15/2021 10:33:58 AM | Browse: 740 | Download: 2260
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Received |
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2021-03-05 06:34 |
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Peer-Review Started |
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2021-03-05 06:37 |
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First Decision by Editorial Office Director |
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2021-04-05 04:46 |
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Return for Revision |
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2021-04-05 04:46 |
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Revised |
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2021-04-07 15:44 |
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Publication Fee Transferred |
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Second Decision by Editor |
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2021-08-10 04:46 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2021-08-10 08:55 |
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Articles in Press |
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2021-08-10 08:55 |
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Edit the Manuscript by Language Editor |
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2021-08-25 00:54 |
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Typeset the Manuscript |
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2021-09-11 13:33 |
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Publish the Manuscript Online |
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2021-09-15 10:33 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Basic Study |
| Article Title |
Proteomics identifies a novel role of fibrinogen-like protein 1 in Crohn’s disease
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Xue-Liang Sun, Li-Chao Qiao, Jing Gong, Ke Wen, Zhi-Zhong Xu and Bo-Lin Yang |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Natural Science Foundation of China |
82074431 |
| The Open Projects of the Discipline of Chinese Medicine of Nanjing University of Chinese Medicine Supported by the Subject of Academic Priority Discipline of Jiangsu Higher Education Institutions |
ZYX03KF034 |
| Suzhou Municipal Science and Technology Bureau |
SYSD2020253 |
| Suzhou Municipal Science and Technology Bureau |
SS202085 |
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| Corresponding Author |
Bo-Lin Yang, MD, Chief Doctor, First Clinical Medical College, the Affiliated Hospital of Nanjing University of Chinese Medicine, Hanzhong 155 Rd, Nanjing 210029, Jiangsu Province, China. yfy0051@njucm.edu.cn |
| Key Words |
Crohn’s disease; Fibrinogen-like protein 1; Proteomics; NF-κB pathway |
| Core Tip |
In this study, fibrinogen-like protein 1 (FGL1) was identified to be significantly upregulated in the plasma and intestinal mucosa of Crohn’s disease (CD) patients. In vitro, silencing FGL1 downregulated the levels of the proinflammatory cytokines IL-1β, IL-6, IL-17 and TNF-α. Furthermore, FGL1 knockdown suppressed the mRNA expression of NF-κB and the protein levels of IKKα, IKKβ, p-IKKα/β, p-IκBα, and p-p65. These results could be reversed by the overexpression of FGL1. Taken together, these data suggest that FGL1 may induce intestinal inflammation by activating the canonical NF-κB signalling pathway and has the potential to be a therapeutic target for CD. |
| Publish Date |
2021-09-15 10:33 |
| Citation |
Sun XL, Qiao LC, Gong J, Wen K, Xu ZZ, Yang BL. Proteomics identifies a novel role of fibrinogen-like protein 1 in Crohn’s disease. World J Gastroenterol 2021; 27(35): 5946-5957 |
| URL |
https://www.wjgnet.com/1007-9327/full/v27/i35/5946.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v27.i35.5946 |
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