Publication Name	World Journal of Respirology
Manuscript ID	65385
Country	Brazil

Received	2021-03-07 13:00
Peer-Review Started	2021-03-07 13:06
To Make the First Decision
Return for Revision	2021-05-06 02:56
Revised	2021-05-17 15:18
Second Decision	2021-07-14 03:33
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2021-07-14 09:34
Articles in Press	2021-07-14 09:34
Publication Fee Transferred
Edit the Manuscript by Language Editor	2021-07-22 04:27
Typeset the Manuscript	2021-07-29 01:20
Publish the Manuscript Online	2021-08-04 03:33

ISSN	2218-6255 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved.
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Category	Respiratory System
Manuscript Type	Case Report
Article Title	Like father, like son: Pulmonary thromboembolism due to inflammatory or hereditary condition? Two case reports
Manuscript Source	Unsolicited Manuscript
All Author List	Pedro Hannun, Walter Hannun, Hugo Hyung Yoo and Lucilene Resende
ORCID	Author(s) ORCID Number Pedro Hannun http://orcid.org/0000-0003-1508-5361 Walter Hannun http://orcid.org/0000-0002-7044-4905 Hugo Hyung Yoo http://orcid.org/0000-0003-3226-2788 Lucilene Resende http://orcid.org/0000-0002-7635-2016
Funding Agency and Grant Number
Corresponding Author	Pedro Hannun, MHSc, MHSc, MHSc, Department of Internal Medicine, Botucatu Medical School, São Paulo State University - UNESP, Prof. Mário Rubens Guimarães Montenegro Avenue, s/n, São Paulo 18618-687, Brazil. pgch2003@gmail.com
Key Words	Factor V Leiden mutation; Thrombophilia; Venous thromboembolism; Deep venous thrombosis; Toxoplasmosis; Inflammation; Case report
Core Tip	This paper describes two closely related patients simultaneously infected by Toxoplasma gondii who concurrently presented their first venous thromboembolism (VTE) episode. Further investigation revealed a factor V Leiden mutation in them both. The association between these 2 morbid conditions suggests that systemic infection/inflammation may enhance the risk of VTE in people carrying this kind of pro-thrombophilia mutation. As far as we know, this is the first report of that association. We believe that this paper provides an insight into this important issue bringing potential help for clinical decision-making processes by doctors around the world.
Publish Date	2021-08-04 03:33
Citation	Hannun P, Hannun W, Yoo HH, Resende L. Like father, like son: Pulmonary thromboembolism due to inflammatory or hereditary condition? Two case reports. World J Respirol 2021; 11(1): 12-17
URL	https://www.wjgnet.com/2218-6255/full/v11/i1/12.htm
DOI	https://dx.doi.org/10.5320/wjr.v11.i1.12

Full Article (PDF)	WJR-11-12.pdf
Full Article (Word)	WJR-11-12.docx
CARE Checklist–2016	65385-CARE-Checklist–2016-revision.pdf
Manuscript File	65385-Review-FilipodiaCL.docx
Answering Reviewers	65385-Answering reviewers.pdf
Audio Core Tip	65385-Audio core tip.m4a
Conflict-of-Interest Disclosure Form	65385-Conflict-of-interest statement.pdf
Copyright License Agreement	65385-Copyright license agreement.pdf
Signed Informed Consent Form(s) or Document(s)	65385-Informed consent statement.pdf
Non-Native Speakers of English Editing Certificate	65385-Language certificate.pdf
Peer-review Report	65385-Peer-review(s).pdf
Scientific Misconduct Check	65385-Bing-Liu M-1.png
Scientific Misconduct Check	65385-Scientific misconduct check.pdf
Scientific Editor Work List	65385-Scientific editor work list.pdf
CrossCheck Report	65385-CrossCheck report.pdf