Publication Name	World Journal of Gastrointestinal Pharmacology and Therapeutics
Manuscript ID	6539
Country	United States

Received	2013-10-23 13:43
Peer-Review Started	2013-10-24 10:13
To Make the First Decision	2013-12-25 18:09
Return for Revision	2013-12-26 11:10
Revised	2014-01-10 03:09
Second Decision	2014-03-04 09:54
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2014-03-04 10:19
Articles in Press
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2014-05-08 20:27
Publish the Manuscript Online	2014-05-20 15:49

ISSN	2150-5349 (online)
Open Access
Copyright
Article Reprints	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Review
Article Title	Histamine2-receptor antagonists: Rapid development of tachyphylaxis with repeat dosing
Manuscript Source	Invited Manuscript
All Author List	Johnson W McRorie, James A Kirby and Philip B Miner
Funding Agency and Grant Number
Corresponding Author	Johnson W McRorie, PhD, FACG, AGAF, Quantitative Sciences, Procter and Gamble, 8700 Mason-Montgomery Road, Mason, OH 45040, United States. mcrorie.jw@pg.com
Key Words	Histamine2-receptor antagonist; Tachyphylaxis; Tolerance; Gastric pH
Core Tip	Histamine2-receptor antagonists (H2RAs) are available over-the-counter (OTC) for the treatment and prevention of heartburn, but recommendations for use should be limited to those with infrequent heartburn. A single dose of an H2RA can be effective for controlling gastric acid and preventing or relieving heartburn, but tolerance (tachyphylaxis) develops rapidly, and is evident by the second day/second dose. Even if symptom relief is achieved, it may be due to desensitization of the esophagus to acid by the H2RA, potentially providing symptom relief without significantly decreasing esophageal acid exposure. For frequent heartburn (≥ 2 d/wk), an OTC proton pump inhibitor should be considered.
Publish Date	2014-05-20 15:49
Citation	McRorie JW, Kirby JA, Miner PB. Histamine2-receptor antagonists: Rapid development of tachyphylaxis with repeat dosing. World J Gastrointest Phar­macol Ther 2014; 5(2): 57-62
URL	http://www.wjgnet.com/2150-5349/full/v5/i2/57.htm
DOI	http://dx.doi.org/10.4292/wjgpt.v5.i2.57

Full Article (PDF)	WJGPT-5-57.pdf
Full Article (Word)	WJGPT-5-57.doc
Manuscript File	6539-Review.docx
Answering Reviewers	6539-Answering reviewers.pdf
Copyright License Agreement	6539-Copyright assignment.pdf
Peer-review Report	6539-Peer review(s).pdf
Scientific Editor Work List	6539-Scientific editor work list.doc