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Articles Published Processes
8/4/2021 7:56:20 AM | Browse: 535 | Download: 1108
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Received |
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2021-03-09 12:38 |
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Peer-Review Started |
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2021-03-09 12:43 |
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To Make the First Decision |
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Return for Revision |
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2021-04-17 13:21 |
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Revised |
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2021-04-30 14:38 |
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Second Decision |
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2021-07-15 03:25 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2021-07-15 07:45 |
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Articles in Press |
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2021-07-15 07:45 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2021-07-30 08:06 |
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Publish the Manuscript Online |
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2021-08-04 07:56 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Engineering, Biomedical |
| Manuscript Type |
Review |
| Article Title |
Hepatitis B virus infection modeling using multi-cellular organoids derived from human induced pluripotent stem cells
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Di Cao, Jian-Yun Ge, Yun Wang, Tatsuya Oda and Yun-Wen Zheng |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Natural Science Foundation of China |
82070638 |
| National Natural Science Foundation of China |
81770621 |
| JSPS KAKENHI |
JP18H02866 |
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| Corresponding Author |
Yun-Wen Zheng, PhD, Associate Professor, Department of Gastrointestinal and Hepato-Biliary-Pancreatic Surgery, Faculty of Medicine, University of Tsukuba, Tennodai 1-1-1, Tsukuba 305-8575, Ibaraki, Japan. ywzheng@md.tsukuba.ac.jp |
| Key Words |
Hepatitis B virus; Induced pluripotent stem cells; Liver organoid; Multi-cellular organoid; Modeling; Transplantable |
| Core Tip |
The development of an effective treatment for hepatitis B virus relies on reliable and reproducible in vitro modeling systems. Recently, three-dimensional multi-cellular organoid systems have attracted considerable attention owing to their superior susceptibility and capability to precisely recapitulate the virus life cycle. Recent advances in organoid-generating strategies, particularly those derived from human induced pluripotent stem cells, together with future improvements in genetic modification and scalability, will undoubtedly promote personalized disease modeling and drug development. |
| Publish Date |
2021-08-04 07:56 |
| Citation |
Cao D, Ge JY, Wang Y, Oda T, Zheng YW. Hepatitis B virus infection modeling using multi-cellular organoids derived from human induced pluripotent stem cells. World J Gastroenterol 2021; 27(29): 4784-4801 |
| URL |
https://www.wjgnet.com/1007-9327/full/v27/i29/4784.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v27.i29.4784 |
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