Publication Name	World Journal of Gastroenterology
Manuscript ID	6556
Country	South Korea

Received	2013-10-24 13:31
Peer-Review Started	2013-10-24 22:53
To Make the First Decision	2014-02-28 19:10
Return for Revision	2014-03-07 17:50
Revised	2014-04-03 01:40
Second Decision	2014-06-05 10:37
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2014-06-05 11:06
Articles in Press	2014-06-05 11:22
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2014-10-16 10:41
Publish the Manuscript Online	2014-10-29 19:34

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
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Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Topic Highlights
Article Title	Small RNA- and DNA-based gene therapy for the treatment of liver cirrhosis, where we are?
Manuscript Source	Invited Manuscript
All Author List	Kyung-Hyun Kim and Kwan-Kyu Park
Funding Agency and Grant Number
Corresponding Author	Kwan-Kyu Park, MD, PhD, Department of Pathology, College of Medicine, Catholic University of Daegu, 3056-6 Daemyung 4-Dong, Nam-Gu, Daegu 705-718, South Korea. kkpark@cu.ac.kr
Key Words	Liver cirrhosis; gene therapy; Oligodeoxynucleotides; Antisense; small interfering RNA; micro RNA; Decoy
Core Tip	Recent advances in understanding the mechanisms underlying liver fibrogenesis, including regulation of inflammatory cytokine signaling, the dynamic process of hepatic stellate cell activation and extracellular matrix degradation. The only option for patients suffering from severe and late-stage cirrhosis is liver transplantation; however, it is limited by the number of available donor organs. Therefore, development of new therapeutic strategies for liver fibrosis and cirrhosis are needed. This review focuses on the recent advances relating to the therapeutic application of liver fibrogenesis through the modulation of gene expression.
Publish Date	2014-10-29 19:34
Citation	Kim KH, Park KK. Small RNA- and DNA-based gene therapy for the treatment of liver cirrhosis, where we are? World J Gastroenterol 2014; 20(40): 14696-14705
URL	http://www.wjgnet.com/1007-9327/full/v20/i40/14696.htm
DOI	http://dx.doi.org/10.3748/wjg.v20.i40.14696

Full Article (PDF)	WJG-20-14696.pdf
Full Article (Word)	WJG-20-14696.doc
Manuscript File	6556-Review.docx
Answering Reviewers	6556-Answering reviewers.pdf
Copyright License Agreement	6556-Copyright assignment.pdf
Peer-review Report	6556-Peer reivew(s).pdf
Scientific Misconduct Check	6556-CrossCheck.jpg
Scientific Editor Work List	6556-Scientific editor work list.pdf