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Articles Published Processes
12/17/2021 8:56:01 AM | Browse: 473 | Download: 983
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Received |
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2021-03-12 19:31 |
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Peer-Review Started |
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2021-03-12 19:39 |
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To Make the First Decision |
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Return for Revision |
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2021-05-01 16:26 |
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Revised |
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2021-05-12 16:07 |
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Second Decision |
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2021-12-06 03:31 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2021-12-08 05:58 |
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Articles in Press |
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2021-12-08 05:58 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2021-12-15 02:18 |
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Publish the Manuscript Online |
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2021-12-17 08:56 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Basic Study |
| Article Title |
Impact of intrarectal chromofungin treatment on dendritic cells-related markers in different immune compartments in colonic inflammatory conditions
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Kunal Kapoor, Nour Eissa, Diane Tshikudi, Charles N Bernstein and Jean-Eric Ghia |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Crohn's and Colitis Canada |
P46601 |
| Canadian Foundation for Innovation |
P39902 |
| Children's Hospital Research Institute of Manitoba |
P45040 |
| Natural Sciences and Engineering Research Council |
P41224 |
| Manitoba Health Research Council |
P41118 |
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| Corresponding Author |
Jean-Eric Ghia, AGAF, MSc, PhD, Associate Professor, Director, Director, Department of Immunology, University of Manitoba, 750 McDermot Ave, Apotex 431, Winnipeg R3E0T5, MB, Canada. jean-eric.ghia@umanitoba.ca |
| Key Words |
Chromofungin; Chromogranin-A; Colitis; Cytokines; Dendritic cells; Gut hormones |
| Core Tip |
Ulcerative colitis (UC) is characterized by a colonic decrease of chromofungin (CHR: chromogranin-A 47-66) and a dysregulation of CD11c+ dendritic cells (DC). Using a UC-like model (dextran sulphate sodium) and biopsies collected from UC patients, we demonstrated a protective effect of CHR via the regulation of DC-related markers and CD11c+ cells at the colonic, mesenteric lymph node and spleen levels, through a potential effect via the NF-κB pathway. In patients with active UC, CHR level showed a negative linear relationship with CD11c+ marker. CHR could be a potential therapy of UC, but larger samples and additional experiments are needed. |
| Publish Date |
2021-12-17 08:56 |
| Citation |
Kapoor K, Eissa N, Tshikudi D, Bernstein CN, Ghia JE. Impact of intrarectal chromofungin treatment on dendritic cells-related markers in different immune compartments in colonic inflammatory conditions. World J Gastroenterol 2021; 27(47): 8138-8155 |
| URL |
https://www.wjgnet.com/1007-9327/full/v27/i47/8138.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v27.i47.8138 |
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