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Articles Published Processes
11/24/2021 9:54:22 AM | Browse: 346 | Download: 662
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Received |
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2021-03-14 08:22 |
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Peer-Review Started |
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2021-03-14 08:39 |
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To Make the First Decision |
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Return for Revision |
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2021-07-18 05:07 |
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Revised |
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2021-07-29 12:07 |
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Second Decision |
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2021-10-12 08:02 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Company Editor-in-Chief |
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2021-10-14 03:01 |
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Articles in Press |
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2021-10-14 03:01 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2021-11-19 00:48 |
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Publish the Manuscript Online |
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2021-11-24 09:54 |
| ISSN |
1948-5182 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Review |
| Article Title |
Heterogeneity of non-alcoholic fatty liver disease: Implications for clinical practice and research activity
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Partha Pal, Rajan Palui and Sayantan Ray |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Sayantan Ray, MBBS, MD, N/A, Department of Endocrinology, Jagannath Gupta Institute of Medical Sciences and Hospital, KP Mondal Road, Budge, Kolkata 700137, West Bengal, India. sayantan.ray30@gmail.com |
| Key Words |
Non-alcoholic fatty liver disease; Metabolic-associated fatty liver disease; Heterogeneity; Phenotypes; nomenclature; Clinical trial; Effective therapies |
| Core Tip |
It is being increasingly recognized that non-alcoholic fatty liver disease (NAFLD) is a heterogenous condition with wide variability in clinical presentation and natural history. This heterogeneity is driven by genetic predisposition, metabolic factors, gut microbiota, diet and demographic factors. The suboptimal response to current pharmacotherapy in NAFLD highlights the failure to recognize this heterogeneity. Experts believe that updating NAFLD nomenclature is the first step towards this. Identification of disease subtypes can help development of preclinical model evaluating novel targets. This would in turn help clinical trial design by comparing and pooling results and thus improve disease outcomes. |
| Publish Date |
2021-11-24 09:54 |
| Citation |
Pal P, Palui R, Ray S. Heterogeneity of nonalcoholic fatty liver disease: Implications for clinical practice and research activity. World J Hepatol 2021; 13(11): 1584-1610 |
| URL |
https://www.wjgnet.com/1948-5182/full/v13/i11/1584.htm |
| DOI |
https://dx.doi.org/10.4254/wjh.v13.i11.1584 |
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